Acute leukemia of ambiguous lineage entities as defined by WHO-HAEM5 and ICC classification
| Acute leukemia of ambiguous lineage . | ||
|---|---|---|
| MPAL with defining genetic alterations | ICC | WHO-HAEM5 |
| MPAL with BCR::ABL1 | ||
| MPAL, with t(v;11q23.3); KMT2A rearranged | ||
| MPAL with ZNF384 rearrangement | ||
| MPAL with BCL11B activation | ALAL with BCL11B rearrangement | |
| MPAL with defining immunophenotypic changes | B/Myeloid MPAL T/Myeloid MPAL B/T/Myeloid MPAL B/T MPAL | MPAL, rare types |
| Acute undifferentiated leukemia (AUL)* | ||
| ALAL*, NOS | ||
| Acute leukemia of ambiguous lineage . | ||
|---|---|---|
| MPAL with defining genetic alterations | ICC | WHO-HAEM5 |
| MPAL with BCR::ABL1 | ||
| MPAL, with t(v;11q23.3); KMT2A rearranged | ||
| MPAL with ZNF384 rearrangement | ||
| MPAL with BCL11B activation | ALAL with BCL11B rearrangement | |
| MPAL with defining immunophenotypic changes | B/Myeloid MPAL T/Myeloid MPAL B/T/Myeloid MPAL B/T MPAL | MPAL, rare types |
| Acute undifferentiated leukemia (AUL)* | ||
| ALAL*, NOS | ||
AUL is defined by a lack of lineage-specific markers.
Rare cases may exist in which the criteria for MPAL are not fulfilled, the criteria for acute leukemia of a single lineage are not fulfilled, and the patient has at least 1 of the lineage-specific markers in Table 2. Such cases are best referred to as acute leukemia of ambiguous lineage, not otherwise specified (ALAL, NOS).