Table 2. Linear alignment of mimotope... | American Society of Hematology

Table 2.

Linear alignment of mimotope clusters on FVIII

Mimotope core motif sequence	FVII sequence	Alignment	Residue number, start	Residue number, end	Domain	No. of surface-accessible residues∗
nxRRPfflnsg	LNSG	LNSG	187	190	A1	0
glggLi	LPGLI	L?GLI	261	265	A1	3
dPxqtll	QTLL	QTLL	316	319	A1	2
GLGqLL	LGQFL	LGQ?L	322	326	A1	4
nqkms	NQIMS	NQ?MS	583	587	A2	5
pdtppSxp	PPSMP	PPS?P	925	929	B	NA†
txxKtxIxTxt	TNRKTHI	T??KT?I	1028	1034	B	NA†
Ppdixspp	PPDAQNP	PPD???P	1105	1111	B	NA†
KVFRxp	KQFRLP	K?FR?P	1335	1340	B	NA†
VFRlpxtxt	FRLP	FRLP	1337	1340	B	NA†
TxltRtls	LTRVL	LTR?L	1423	1427	B	NA†
qNLsl	NLSL	NLSL	1461	1464	B	NA†
ydkadnerarlg	YDEDENQSPR	YD???N???R	1699	1708	other	NA†
dRxeLNmxxxl	RGELN	R?ELN	1768	1772	A3	3
lNEvLv	LNEHL	LNE?L	1771	1775	A3	3
hTnln	HTNTLN	HTN-LN	1878	1883	A3	4
kxDiLaxl	KVDLLA	K?D?LA	2091	2096	C1	3
KxDssGP	DSSG	DSSG	2150	2153	C1	3

Mimotope core motif sequence	FVII sequence	Alignment	Residue number, start	Residue number, end	Domain	No. of surface-accessible residues∗
nxRRPfflnsg	LNSG	LNSG	187	190	A1	0
glggLi	LPGLI	L?GLI	261	265	A1	3
dPxqtll	QTLL	QTLL	316	319	A1	2
GLGqLL	LGQFL	LGQ?L	322	326	A1	4
nqkms	NQIMS	NQ?MS	583	587	A2	5
pdtppSxp	PPSMP	PPS?P	925	929	B	NA†
txxKtxIxTxt	TNRKTHI	T??KT?I	1028	1034	B	NA†
Ppdixspp	PPDAQNP	PPD???P	1105	1111	B	NA†
KVFRxp	KQFRLP	K?FR?P	1335	1340	B	NA†
VFRlpxtxt	FRLP	FRLP	1337	1340	B	NA†
TxltRtls	LTRVL	LTR?L	1423	1427	B	NA†
qNLsl	NLSL	NLSL	1461	1464	B	NA†
ydkadnerarlg	YDEDENQSPR	YD???N???R	1699	1708	other	NA†
dRxeLNmxxxl	RGELN	R?ELN	1768	1772	A3	3
lNEvLv	LNEHL	LNE?L	1771	1775	A3	3
hTnln	HTNTLN	HTN-LN	1878	1883	A3	4
kxDiLaxl	KVDLLA	K?D?LA	2091	2096	C1	3
KxDssGP	DSSG	DSSG	2150	2153	C1	3

SD, standard deviation.

The number of surface-accessible residues for each alignment was calculated using the GETAREA algorithm, as described in “Methods.”

No information on surface-accessibility of B domain and some adjacent residues.