Table 2. Compound mediated cytotoxic... | American Society of Hematology

Table 2.

Compound mediated cytotoxic activity of T cells against MOLM-13, U-937, and KG-1a target cells

Sample ID	Human T cells (n > 4)						Cynomolgous T cells (n = 1)
	MOLM-13		KG-1a		U-937		MOLM-13 (n = 1)
	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis
CD33/CD3 BiTE AMG 330	8.5E−12	32	1.3E−11	<10	1.0E−11	54	1.9E−11	23
CD123/CD3 DART MGD006	1.9E−12	37	3.7E−12	57	No fit	No killing	2.7E−12	37
CD33/CD123 TCE	1.8E−11	36	2.8E−10	52	6.7E−10	52	1.4E−11	37

Sample ID	Human T cells (n > 4)						Cynomolgous T cells (n = 1)
	MOLM-13		KG-1a		U-937		MOLM-13 (n = 1)
	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis	EC₅₀ (M)	% lysis
CD33/CD3 BiTE AMG 330	8.5E−12	32	1.3E−11	<10	1.0E−11	54	1.9E−11	23
CD123/CD3 DART MGD006	1.9E−12	37	3.7E−12	57	No fit	No killing	2.7E−12	37
CD33/CD123 TCE	1.8E−11	36	2.8E−10	52	6.7E−10	52	1.4E−11	37

The global geometric EC₅₀ was calculated from different dose response curves using T cells of different healthy donors. Data are from at least 4 experiments for human T cells, only 1 experiment with cynomolgous T cells.

[ViewLarge]

This Feature Is Available To Subscribers Only