Features of CHIP, ICUS, CCUS, and MDS
| . | Cytopenia/dysplasia . | VAF cutoff . | Commonly mutated driver genes . | Higher risk features . |
|---|---|---|---|---|
| CHIP | No/Minimal (<10%) to none | >2% | DNMT3A, TET2, ASXL1, PPM1D, JAK2, ZBTB33, ZNF318, TP53, CBL, GNB1, SF3B1, SRSF2, loss of Y chromosome | Mutations in TP53, ASXL1, JAK2, SF3B1, SRSF2, U2AF1, or IDH1/IDH2; >1 driver mutations; VAF > 10% |
| ICUS | Yes/Minimal (<10%) to none | None | None | None |
| CCUS | Yes/Minimal (<10%) to none | >2% | TET2, DNMT3A, ASXL1, SRSF2, ZRSR2, SF3B1, U2AF1, IDH1/2, RUNX1, EZH2, JAK2, CBL, KRAS, CUX1, TP53 | Spliceosome gene mutations DNMT3A, ASXL1, TET2 in comutational patterns (RUNX1, EZH2, CBL, BCOR, CUX1, TP53, or IDH1/IDH2 most specific), >1 driver mutation; VAF > 10% |
| MDS | Yes/Yes | None | See text | See text |
| . | Cytopenia/dysplasia . | VAF cutoff . | Commonly mutated driver genes . | Higher risk features . |
|---|---|---|---|---|
| CHIP | No/Minimal (<10%) to none | >2% | DNMT3A, TET2, ASXL1, PPM1D, JAK2, ZBTB33, ZNF318, TP53, CBL, GNB1, SF3B1, SRSF2, loss of Y chromosome | Mutations in TP53, ASXL1, JAK2, SF3B1, SRSF2, U2AF1, or IDH1/IDH2; >1 driver mutations; VAF > 10% |
| ICUS | Yes/Minimal (<10%) to none | None | None | None |
| CCUS | Yes/Minimal (<10%) to none | >2% | TET2, DNMT3A, ASXL1, SRSF2, ZRSR2, SF3B1, U2AF1, IDH1/2, RUNX1, EZH2, JAK2, CBL, KRAS, CUX1, TP53 | Spliceosome gene mutations DNMT3A, ASXL1, TET2 in comutational patterns (RUNX1, EZH2, CBL, BCOR, CUX1, TP53, or IDH1/IDH2 most specific), >1 driver mutation; VAF > 10% |
| MDS | Yes/Yes | None | See text | See text |