Table 2. Diagnostic criteria for... | American Society of Hematology

Table 2.

Diagnostic criteria for accelerated and blast phase chronic myeloid leukemia (CML)

Accelerated phase	Blast phase
Bone marrow or peripheral blood blasts 10%-19%	Bone marrow or peripheral blood blasts ≥ 20%
Peripheral blood basophils ≥ 20%	Myeloid sarcoma†
Presence of additional clonal cytogenetic abnormality in Ph+ cells (ACA)*	Presence of morphologically apparent lymphoblasts (>5%) warrants consideration of lymphoblastic crisis‡

Accelerated phase	Blast phase
Bone marrow or peripheral blood blasts 10%-19%	Bone marrow or peripheral blood blasts ≥ 20%
Peripheral blood basophils ≥ 20%	Myeloid sarcoma†
Presence of additional clonal cytogenetic abnormality in Ph+ cells (ACA)*	Presence of morphologically apparent lymphoblasts (>5%) warrants consideration of lymphoblastic crisis‡

Ph, Philadelphia chromosome.

Second Ph, trisomy 8, isochromosome 17q, trisomy 19, complex karyotype, or abnormalities of 3q26.2.

Extramedullary blast proliferation.

Immunophenotypic analysis is required to confirm lymphoid lineage.