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Stephane de Botton
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Journal Articles

Clonal persistence of BRAFV600E under MEK inhibition in histiocytosis

Free
Marzieh Nashvi, David Fandrei, Florian Houdu, Paul Quentric, Irena Ungureanu, Matthias Papo, Lise Drouart, Marion Peyre, Jessica Rengassamy, Zofia Hélias-Rodzewicz, Nathalie Droin, Rémy Jélin, Cyril Quivoron, Stephane De Botton, Jean Donadieu, Jean-Francois Emile, Elsa Bernard, Sébastien Héritier, Julien Haroche, Camille Bigenwald
Journal: Blood
Blood (2025) 146 (Supplement 1): 1495.
https://doi.org/10.1182/blood-2025-1495
Published: 2025
Journal Articles

CYP3A4 inhibitors (CYP3A4i) and myelosuppression in patients (Pts) with newly diagnosed mutant isocitrate dehydrogenase 1 (mIDH1) Acute Myeloid Leukemia (AML) in the phase 3 AGILE study

Free
Andre Schuh, Pau Montesinos, Christian Recher, Michael Heuser, Susana Vives, Ewa Zarzycka, Marta Riva, Rodrigo Calado, Su-Peng Yeh, Courtney DiNardo, Mohammad Hossain, Jianan Hui, Diego Gianolio, Assaf Vestin, Rui Ding, Prapti Patel, Stéphane De Botton, Hartmut Döhner, Jianxiang Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3440.
https://doi.org/10.1182/blood-2025-3440
Published: 2025
Journal Articles

Analysis of hematologic improvement (HI) by time to response in Relapsed/Refractory Acute Myeloid Leukemia (AML) patients treated with olutasidenib

Free
Shira Dinner, Brian Jonas, Antonio Curti, Stephane De Botton, Pau Montesinos, Karen W.L. Yee, Gail Roboz, William Blum, Gary Schiller, Jorge Cortes, Justin Watts, Andrew Wei, Aaron Sheppard, Hua Tian, Eunice Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 3439.
https://doi.org/10.1182/blood-2025-3439
Published: 2025
Journal Articles

Revumenib for patients with relapsed or refractory (R/R) Nucleophosmin 1–Mutated (NPM1m) Acute Myeloid Leukemia (AML): Outcomes by prior treatment in the phase 2 AUGMENT-101 study

Free
Martha Arellano, Michael Thirman, John DiPersio, Mael Heiblig, Eytan Stein, Andre Schuh, Andrius Zucenka, Stephane De Botton, Carolyn Grove, Gabriel Mannis, Cristina Papayannidis, Alexander Perl, Ghayas Issa, Ibrahim Aldoss, Ashish Bajel, David Dickens, Michael Kühn, Ioannis Mantzaris, Emmanuel Raffoux, Elie Traer, Irina Amitai, Hartmut Döhner, Corinna Greco, Tibor Kovacsovics, Christine McMahon, Pau Montesinos, Arnaud Pigneux, Paul Shami, Richard Stone, Ofir Wolach, John Harpel, Yakov Chudnovsky, Li Yu, Rebecca Bagley, Angela R. Smith, James Blachly
Journal: Blood
Blood (2025) 146 (Supplement 1): 3418.
https://doi.org/10.1182/blood-2025-3418
Published: 2025
Journal Articles

Randomized study of high-dose cytarabine with or without dexamethasone as post-remission therapy in younger adults with newly diagnosed AML – the french backbone intergroup (BIG)-1 study on behalf of the filo, ALFA, and SFGM-TC study groups

Free
Christian Recher, Marie-Anne Hospital, Thibaut Leguay, Martin Carre, Corentin Orvain, Caroline Bonmati, Emmanuel Raffoux, Celestine Simand, Romain Guieze, Jamilé Frayfer, Juliette Lambert, Sylvain Chantepie, Marc Bernard, Pierre Peterlin, Magda Alexis, Pascal Turlure, Cecile Pautas, Sarah Bertoli, Ludovic Gabellier, Edouard Forcade, Nicolas Duployez, Isabelle Luquet, Dominique Penther, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Pierre-Yves Dumas, Eric Delabesse, Claude Preudhomme, Jean-François Hamel, Herve Dombret, Arnaud Pigneux, Hunault-Berger Mathilde, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 881.
https://doi.org/10.1182/blood-2025-881
Published: 2025
Journal Articles

Comprehensive mutational profiling and clinical outcome of adults AML with NUP98 rearrangement

Free
Ducourneau Benoit, Arnaud Pages, Stéphanie Struski, Matthieu Decamp, Emmanuel Raffoux, Céline Berthon, Laurene Fenwarth, Vincent Marmouset, Cecile Pautas, Thomas Cluzeau, Delphine Lebon, Madalina Uzunov, Patricio Pereyra, Mael Heiblig, Jean-Valère Malfuson, Laure Farnault, Pierre-Yves Dumas, Julia HIEULLE, Sarah Bertoli, Sylvain Chantepie, Nathalie Auger, Audrey Bidet, Marie Joelle Mozziconacci, Augustin Boudry, Isabelle Luquet, Laureen Chat, Romain Loyaux, Lina EL-MURR, Emmanuelle Clappier, Claude Gardin, Mathilde Hunault, Stephane De Botton, Arnaud Pigneux, Dominique Penther, Eric Delabesse, Raphael Itzykson, Claude Preudhomme, Herve Dombret, Christian Recher, Nicolas Duployez, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 7002.
https://doi.org/10.1182/blood-2025-7002
Published: 2025
Journal Articles

Clinical and biological correlates of blast-transformed chronic myelomonocytic leukemia (CMML): A multicenter study of 493 paired cases at chronic phase and at blast transformation

Free
Clifford Csizmar, Guillermo Montalban-Bravo, Leila Cysique-Foinlan, Anuya Natu, Terra Lasho, Christy Finke, Aref Al-Kali, Hassan Alkhateeb, Ali Alsugair, Kebede Begna, Saubia Fathima, Naseema Gangat, Abhishek Mangaonkar, Antoine Saliba, Ayalew Tefferi, Margot Morabito, Nathalie Droin, Cyril Quivoron, Benjamin Podvin, Nicolas Duployez, Olivier Kosmider, Christophe Marzac, Sylvain Thépot, Mathieu Meunier, Céline Berthon, Thorsten Braun, Christophe Willekens, Stephane De Botton, Lionel Ades, Alexandre Bazinet, Kelly Chien, Danielle Hammond, Courtney DiNardo, Tapan Kadia, Rashmi Kanagal-Shamanna, Sanam Loghavi, Naveen Pemmaraju, Farhad Ravandi, Koji Sasaki, Hagop Kantarjian, Pierre Fenaux, Eric Solary, Guillermo Garcia-Manero, Aline Renneville, Mrinal Patnaik
Journal: Blood
Blood (2025) 146 (Supplement 1): 2081.
https://doi.org/10.1182/blood-2025-2081
Published: 2025
Journal Articles

Venetoclax in combination with hypomethylating agents in adult patients with newly diagnosed AML with CBFB::MYH11 or RUNX1::RUNX1T1 fusions: Real-world outcomes based on international registry data

Free
Leo Ruhnke, Christoph Röllig, Lydia Kretschmer, Jan Moritz Middeke, Sylvia Herold, David Poitz, Pau Montesinos, Maria Del Carmen Martinez Chamorro, Josefina Serrano, Joaquín Sánchez-García, Lara María Gómez García, Francisco-Javier Peñalver, Guillermo Quintero, Virginia Abello, Pierre Yves Dumas, Sarah Bertoli, Christian Recher, Arnaud Pigneux, Jenny O'Nions, Hannah Al-Yousuf, Jad Othman, Richard Dillon, Jiri Mayer, Stephane De Botton, Raphael Itzykson, Herve Dombret, Magdalena Czemerska, Agnieszka Wierzbowska, Anne Weigert, Madlen Jentzsch, Uwe Platzbecker, Karsten Spiekermann, Tim Sauer, Carsten Müller-Tidow, Hubert Serve, Claudia Baldus, Martin Bornhäuser, Klaus Metzeler
Journal: Blood
Blood (2025) 146 (Supplement 1): 5230.
https://doi.org/10.1182/blood-2025-5230
Published: 2025
Journal Articles

Olutasidenib monotherapy in patients with mIDH1 Acute Myeloid Leukemia who received prior intensive chemotherapy

Free
Jay Yang, Joseph Jurcic, Christian Recher, Pierre Fenaux, Andrew Wei, Antonio Curti, Justin Watts, Eunice Wang, Brian Jonas, Jorge Cortes, Aaron Sheppard, Sophia Wang, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 5213.
https://doi.org/10.1182/blood-2025-5213
Published: 2025
Journal Articles

Real-life CD34+CD38- leukemic stem cell (LSC) flow quantification in adult AML at diagnosis independently predicts survival of intensively but not AZA-VEN treated patients: A study of prospective observational ALFA-PPP acute leukemia french association

Free
Adriana Plesa, Alexandra COELHO, Stéphanie Mathis, Veronique Saada, Isabelle Arnoux, Valerie Bardet, Florent Dumezy, Clémentine Chauvel, Jaja Zhu, Vanessa Nivaggioni, Delphine Manzoni, Iole Oster, Dominique Penther, Nicolas Duployez, Karine Celli-Lebras, Nicole Raus, Emmanuel Raffoux, Lionel Ades, Christophe Willekens, Jean-Baptiste Micol, Stephane De Botton, Laure Farnault, Sylvain Chantepie, Thomas Cluzeau, Julia HIEULLE, Céline Berthon, Ahmad Aljijakli, Claire Bories, Kevin-James Wattebled, Renaud Buffet, Raphael Itzykson, Hervé Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2025) 146 (Supplement 1): 3483.
https://doi.org/10.1182/blood-2025-3483
Published: 2025
Journal Articles

Frequency and impact of FLT3-ITD microclones in younger AML patients

Free
Nicolas Duployez, Romane Joudinaud, Augustin Boudry, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Raja Prince-Eladnani, Mael Heiblig, Sylvain Chantepie, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Felipe Suarez, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Raphael Itzykson, Eric Delabesse, Jean-François Hamel, Stephane De Botton, Arnaud Pigneux, Herve Dombret, Christian Recher, Claude Preudhomme, Pierre-Yves Dumas
Journal: Blood
Blood (2025) 146 (Supplement 1): 456.
https://doi.org/10.1182/blood-2025-456
Published: 2025
Journal Articles

Real-world patterns of treatment intensity and prognostic model performance in older AML: Insights from the french ALFA-PPP cohort

Free
Lin-Pierre Zhao, Céline Berthon, Lauren Fenwarth, Stephane De Botton, Thomas Cluzeau, Laure Farnault, Sylvain Chantepie, Pierre Arnautou, Thorsten Braun, Mathieu Leclerc, Delphine Lebon, Ahmad Aljijakli, Isabelle Plantier, Ollivier Legrand, Juliette Lambert, Christophe Willekens, Emmanuel Raffoux, Claire Bories, Emilie Lemasle, Kevin-James Wattebled, Ambroise Marçais, Celia Salanoubat, Pascal Turlure, Jamilé Frayfer, Benjamin Carpentier, Madalina Uzunov, Reda Garidi, Ioana Vaida, Renaud Buffet, Alexandra COELHO, Karine Celli-Lebras, Raphael Itzykson, Claude Preudhomme, Nicolas Duployez, Hervé Dombret, Lionel Ades
Journal: Blood
Blood (2025) 146 (Supplement 1): 454.
https://doi.org/10.1182/blood-2025-454
Published: 2025
Journal Articles

Real life treatments and outcomes of older patients aged more than 60 years with FLT3-mutated acute myeloid leukemia: Report from the multicentric french observational ALFA-PPP study

Free
Ramy Rahmé, Emmanuel Raffoux, Lionel Ades, Stephane De Botton, Nicolas Duployez, Alexandra COELHO, Jean-Baptiste Micol, Sylvain Chantepie, Thomas Cluzeau, Delphine Lebon, Pierre Arnautou, Mathieu Leclerc, Laure Farnault, Ollivier Legrand, Ahmad Aljijakli, Céline Berthon, Juliette Lambert, Claire Bories, Ambroise Marçais, Julia HIEULLE, Celia Salanoubat, Pascal Turlure, Kevin-James Wattebled, Benjamin Carpentier, Jamile Frayfer, Ioana Vaida, Madalina Uzunov, Reda Garidi, Luca Inchiappa, Karine Celli-Lebras, Dominique Penther, Raynier Devillier, Raphael Itzykson, Claude Preudhomme, Renaud Buffet, Herve Dombret, Thorsten Braun
Journal: Blood
Blood (2025) 146 (Supplement 1): 449.
https://doi.org/10.1182/blood-2025-449
Published: 2025
Journal Articles

Prospective monitoring of 591 cancer patients with clonal hematopoiesis detected in daily practice

Free
Mégane Tanguay, David Fandrei, Michael Degaud, Ahmadreza Arbab, Romain Loyaux, Damien Vasseur, Arnaud Bayle, Mihaela Aldea, Véronique Vergé, Gérôme Jules-Clément, Sofiane Taleb, Christophe Willekens, Florence Pasquier, Cristina Castilla-Llorente, Camille Bigenwald, David Ghez, Alice Fievet, Eric Solary, Stephane De Botton, Fabrice Barlesi, Fabrice André, Ludovic Lacroix, Etienne Rouleau, Antoine Italiano, Christophe Marzac, Elsa Bernard, Aline Renneville, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 6708.
https://doi.org/10.1182/blood-2025-6708
Published: 2025
Journal Articles

Impact of midostaurin in younger AML patients intensively treated with high-dose anthracycline

Free
Pierre-Yves Dumas, Mathieu Leclerc, Mathilde Hunault, Emmanuelle Tavernier, Cecile Pautas, Sarah Bertoli, Thibaut Leguay, Suzanne Tavitian, Emmanuel Raffoux, Marie-Anne Hospital, Sylvain Chantepie, Mael Heiblig, Martin Carre, Pierre Peterlin, Maria Pilar Gallego Hernanz, Romain Guieze, Célestine Simand, Pascal Turlure, Anne Huynh, Emilie Lemasle, Ludovic Gabellier, Juliette Lambert, Delphine Lebon, Madalina Uzunov, Jean-Valère Malfuson, Thomas Cluzeau, Samy Chraibi, Laurence Sanhes, Karine Celli-Lebras, Ariane Mineur, Claude Gardin, Norbert Ifrah, Norbert Vey, Regis Peffault De Latour, Isabelle Luquet, Dominique Penther, Eric Delabesse, Jean-François Hamel, Raphael Itzykson, Claude Preudhomme, Stephane De Botton, Nicolas Duployez, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2025) 146 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2025-1682
Published: 2025
Journal Articles

Clinical characteristics and response in olutasidenib-treated Relapsed/Refractory mIDH1 Acute Myeloid Leukemia (AML) patients with stable disease following two treatment cycles

Free
Justin Watts, Eunice Wang, Brian Jonas, William Donnellan, Jay Yang, Karen Seiter, Andrew Wei, Stephane De Botton, Amber Thomassen, Hua Tian, Jorge Cortes
Journal: Blood
Blood (2025) 146 (Supplement 1): 1659.
https://doi.org/10.1182/blood-2025-1659
Published: 2025
Journal Articles

Real life study of ivosidenib in either monotherapy or combined with azacytidine for first line mutant IDH1 AML: A study from the french AML intergroup ALFA/filo

Free
Pierre Peterlin, Mael Heiblig, Stéphane Morisset, Sarah Bertoli, Marie Sebert, Thomas Cluzeau, Corentin Orvain, Pierre-Yves Dumas, Paolo Musiu, Sylvain Garciaz, Yohan Desbrosses, Gaspar Aspas Requena, Rudy Birsen, Pascal Turlure, Celestine Simand, Adrien Contejean, Celia Salanoubat, Benjamin Carpentier, Ambroise Marçais, Juliette Lambert, Delphine Lebon, Quentin Cabrera, Sarah Bonnet, Kamel Laribi, Anne Banos, Adrien Daniel, Marlene Ochmann, Cecile Pautas, Benjamin Papoular, Jamile Frayfer, Gian Matteo Pica, Julia HIEULLE, Nicolas Vallet, Ariane Mineur, Arnaud Pigneux, Christian Recher, Stephane De Botton
Journal: Blood
Blood (2025) 146 (Supplement 1): 1658.
https://doi.org/10.1182/blood-2025-1658
Published: 2025
Journal Articles

Secondary-type acute myeloid leukemia is associated with a higher risk of invasive fungal infection during intensive induction therapy. a correlative study on the ALFA 0702 trial.

Free
Jean-Eudes Fahrner, Mauricette Michallet, Laurene Fenwarth, Mohamad Sobh, Stéphane Morisset, Alexandre Deloire, Emmanuel Raffoux, Stephane De Botton, Sylvain Chantepie, Stephane Girault, Céline Berthon, Sarah Bertoli, Stephane Lepretre, Pierre Yves Dumas, Juliette Lambert, Delphine Lebon, Cecile Pautas, Jean Valère Malfuson, Norbert Vey, Thorsten Braun, Felipe Suarez, Aline Schmidt, Remy Gressin, Caroline Bonmati, Karine Celli-Lebras, Mael Heiblig, Mohamed El-Hamri, Claude Preudhomme, Hervé Dombret, Anne Bergeron, Nicolas Duployez, Raphael Itzykson
Journal: Blood
Blood (2025) 146 (Supplement 1): 994.
https://doi.org/10.1182/blood-2025-994
Published: 2025
Journal Articles

Therapy-related core binding factor Acute Myeloid Leukemia – a Study of the french acute leukemia intergroup

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Mathilde Chanut, Loïc Vasseur, Matthieu Duchmann, Pierre Hirsch, Céline Berthon, Mael Heiblig, Thorsten Braun, Mathieu Leclerc, Jean Valère Malfuson, Delphine Lebon, Madalina Uzunov, Jean-Noel Bastie, Gian Matteo Pica, Marie-Anne Hospital, Thomas Cluzeau, Juliette Lambert, Lauris Gastaud, Karine Celli-Lebras, Arnaud Pigneux, Stephane De Botton, Christian Recher, Claude Preudhomme, Eric Jourdan, Herve Dombret, Nicolas Boissel, Nicolas Duployez, Raphael Itzykson, Jean-Baptiste Micol
Journal: Blood
Blood (2025) 146 (Supplement 1): 37.
https://doi.org/10.1182/blood-2025-37
Published: 2025
Journal Articles

Treatments and outcomes of adult patients with TP53-mutated acute myeloid leukemia (AML) in the real-life –Report of the prospective french observational ALFA-PPP study.

Free
Jean-Baptiste Micol, Raphael Itzykson, Laure Farnault, Thomas Cluzeau, Jean-Valère Malfuson, Sylvain Chantepie, Delphine Lebon, Claire Bories, Ramy Rahme, Mathieu Leclerc, Ahmad Aljijakli, Laurene Fenwarth, Alexandra COELHO, Renaud Buffet, Emmanuel Raffoux, Christophe Willekens, Marie Sebert, Stephane De Botton, Claude Preudhomme, Herve Dombret, Dominique Penther, Nicolas Duployez, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 6386.
https://doi.org/10.1182/blood-2025-6386
Published: 2025