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Journal Articles

Pirtobrutinib in post-cbtki CLL/SLL: Final update from the Phase 1/2 BRUIN study with more than 5 years follow-up

Free
William Wierda, Jennifer Brown, Paolo Ghia, Lindsey Roeker, Krish Patel, Toby Eyre, Talha Munir, Ewa Lech-Maranda, Nicole Lamanna, Constantine Tam, John Seymour, Benoit Tessoulin, Nirav Shah, Chaitra Ujjani, Bita Fakhri, Catherine Coombs, Ian Flinn, Manish Patel, Sunita Dwivedy Nasta, Jonathon Cohen, Alvaro Alencar, Chan Cheah, Shuo Ma, Joanna Rhodes, Deepa Jagadeesh, Pier Luigi Zinzani, Anders Österborg, Koji Izutsu, Noriko Fukuhara, Donald Tsai, Paolo Abada, Minna Balbas, Jian Li, Ying (denise) Wang, Wojciech Jurczak, Jennifer Woyach
Journal: Blood
Blood (2025) 146 (Supplement 1): 2115.
https://doi.org/10.1182/blood-2025-2115
Published: 2025
Journal Articles

Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis

Free
John Mascarenhas, Joseph Scandura, Vikas Gupta, Kazuya Shimoda, James McCloskey, Firas El Chaer, Prithviraj Bose, Raajit Rampal, Andrew Srisuwananukorn, Timothy Devos, Ruben Mesa, Professor Francesco Passamonti, Srinivas Tantravahi, David Ross, Lindsay Rein, Jean-Jacques Kiladjian, Takanori Teshima, Takuji Yamauchi, Noboru Asada, Anna Halpern, Tamanna Haque, Etienne Paubelle, Noriko Fukuhara, Pankit Vachhani, Michiko Ichii, Ronald Hoffman, Marcello Rotta, Michael Keng, Stefan Wickenhauser, Karen Ansaldo, Masataka Seki, Jinny Lee, Vincent Loksa, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2025) 146 (Supplement 1): 482.
https://doi.org/10.1182/blood-2025-482
Published: 2025
Journal Articles

Cell intrinsic heme synthesis supports glycolysis for activation of naive CD4+ T cell

Free
Kazuki Sakurai, Hiroki Kato, Yan Yan, Sayaka Sano, Daigo Michimata, Kazuki Hashimoto, Naoya Morota, Hiroka Komatsu, Tatsuya Watanabe, Daichi Kiba, Yuya Tanaka, Koichi Onodera, Shunsuke Hatta, Yasushi Onishi, Toru Fujiwara, Noriko Fukuhara, Hideo Harigae
Journal: Blood
Blood (2025) 146 (Supplement 1): 627.
https://doi.org/10.1182/blood-2025-627
Published: 2025
Journal Articles

Nuvisertib, an oral investigational selective PIM1 kinase inhibitor, showed clinical responses strongly correlating with cytokine modulation in patients with relapsed/refractory myelofibrosis in the ongoing global phase I/II study

Free
Lindsay Rein, Firas El Chaer, Junichiro Yuda, Joseph Scandura, Shuichi Shirane, Kazuya Shimoda, Prithviraj Bose, Akiyoshi Takami, Alessandra Iurlo, Michiko Ichii, James McCloskey, Michael Keng, Samah Alimam, Noriko Fukuhara, Nikki Granacher, Giulia Benevolo, Alessandro Lucchesi, Tamanna Haque, Jean-Jacques Kiladjian, Srinivas Tantravahi, Pankit Vachhani, Anand Patel, Stanley Cheung, Paul Yeh, Francesca Palandri, Ashwin Kishtagari, Ciro Rinaldi, Marcello Rotta, Vincent Ribrag, Michael Loschi, Idoroenyi Amanam, Terrence Bradley, Karen Ansaldo, Masataka Seki, Guia Guffanti, Jinny Lee, Prasanthi Pellakuru, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2025) 146 (Supplement 1): 2018.
https://doi.org/10.1182/blood-2025-2018
Published: 2025
Journal Articles

Comparison of Clinical Characteristics and Prognosis between Aggressive NK-Cell Leukemia and Advanced-Stage Extranodal NK/T-Cell Lymphoma

Free
Ayumi Fujimoto, Kana Miyazaki, Takeshi Maeda, Kimikazu Yakushijin, Wataru Munakata, Takahiro Fujino, Yasuo Ejima, Nobuhiro Hiramoto, Noriko Fukuhara, Jun Takizawa, Dai Maruyama, Nobuko Kubota, Hideki Goto, Rika Sakai, Senzo Taguchi, Naoko Asano, Fumihiro Ishida, Motoko Yamaguchi, Ritsuro Suzuki
Journal: Blood
Blood (2024) 144 (Supplement 1): 1682.
https://doi.org/10.1182/blood-2024-205065
Published: 2024
Journal Articles

Trial in Progress: Phase 1/2 Study of Cereblon-Modulating Agent Golcadomide (BMS-986369/CC-99282) in Relapsed or Refractory (R/R) T-Cell Lymphomas (TCLs) (GOLSEEK-3)

Free
Koji Izutsu, Noriko Fukuhara, Makoto Sugaya, Yuichi Baba, Jin Hayakawa, Mitsufumi Nishio, Alev Akyol, Akshay Sudhindra, Kenji Ishitsuka
Journal: Blood
Blood (2024) 144 (Supplement 1): 3123.3.
https://doi.org/10.1182/blood-2024-203202
Published: 2024
Journal Articles

RNA Methyltransferase Mettl16 Is Indispensable for the Survival of Naïve CD4 + T Cells In Vivo

Free
Daigo Michimata, Hiroki Kato, Naoya Morota, Yuya Tanaka, Kazuki Sakurai, Kazuki Hashimoto, Koichi Onodera, Shunsuke Hatta, Yasushi Onishi, Noriko Fukuhara, Hideo Harigae
Journal: Blood
Blood (2024) 144 (Supplement 1): 2534.
https://doi.org/10.1182/blood-2024-198338
Published: 2024
Journal Articles

Number of Sites of Involvement Predicts Central Nervous System Relapse in Patients with Localized Extranodal Natural Killer/T-Cell Lymphoma

Free
Yuma Nato, Kana Miyazaki, Ayumi Fujimoto, Senzo Taguchi, Naoko Asano, Jun Amaki, Wataru Munakata, Yuko Shirouchi, Nobuko Kubota, Takeshi Maeda, Jun Takizawa, Kimikazu Yakushijin, Rika Sakai, Hideyuki Nakazawa, Masahiro Takeuchi, Noriko Fukuhara, Yuri Miyazawa, Ryoji Tokiya, Tohru Murayama, Isao Tawara, Yasuo Ejima, Ritsuro Suzuki, Motoko Yamaguchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3058.
https://doi.org/10.1182/blood-2024-198371
Published: 2024
Journal Articles

Transcription Factor Gata2 Regulates the Myeloid-Lymphoid Fate Decision in Multipotent Progenitors

Free
Yuya Tanaka, Hiroki Kato, Sayaka Sano, Daigo Michimata, Kazuki Sakurai, Kazuki Hashimoto, Naoya Morota, Koichi Onodera, Shunsuke Hatta, Noriko Fukuhara, Yasushi Onishi, Tohru Fujiwara, Hideo Harigae
Journal: Blood
Blood (2024) 144 (Supplement 1): 4037.
https://doi.org/10.1182/blood-2024-207236
Published: 2024
Journal Articles

Randomized Phase III Study of Watchful Waiting Vs. Rituximab As First-Line Treatment in Patients with Advanced Stage Low Tumor Burden Follicular Lymphoma: JCOG1411/Flora Study

Free
Noriko Fukuhara, Dai Maruyama, Kenichi Ishizawa, Yusuke Sano, Ryunosuke Machida, Shinichi Makita, Wataru Munakata, Satoshi Ichikawa, Keiko Aizawa, Kana Miyazaki, Yoshihiro Kameoka, Shinya Rai, Yu Yagi, Naoki Takahashi, Toshiki Mushino, Takeharu Kato, Yuri Miyazawa, Toko Saito, Kazuyuki Shimada, Junya Kuroda, Hideki Uryu, Yuko Mishima, Nobuyuki Takayama, Yasuhiro Suzuki, Toshiki Uchida, Nobuhiko Nakamura, Takayuki Tabayashi, Yosuke Minami, Nobuaki Dobashi, Kunihiro Tsukasaki, Hirokazu Nagai
Journal: Blood
Blood (2024) 144 (Supplement 1): 338.
https://doi.org/10.1182/blood-2024-199868
Published: 2024
Journal Articles

A Multicenter, Prospective, Observational Study of Pola-R-CHP in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma (POLASTAR): A Preliminary Analysis

Free
Hirohiko Shibayama, Atsushi Satake, Kohta Miyawaki, Yuki Fujiwara, Shuichi Ota, Tsuyoshi Muta, Shinya Rai, Hisashi Tsurumi, Ritsuro Suzuki, Takaaki Miyake, Hideki Goto, Noriko Fukuhara, Mamiko Sakata-Yanagimoto, Koji Izutsu, Momoko Nishikori, Takahiro Kumode, Daisuke Ennishi, Takayuki Shimose, Naoki Inubashiri, Itaru Matsumura, Koichi Akashi, Koji Kato
Journal: Blood
Blood (2024) 144 (Supplement 1): 4475.
https://doi.org/10.1182/blood-2024-192949
Published: 2024
Journal Articles

Safety Profile of Infectious Events for First-Line Pola-R-CHP Therapy in Elderly Patients with Diffuse Large B-Cell Lymphoma Including Those 80+ Years Old in Japan

Free
Yo Saito, Tetsuro Oda, Shimpei Nakanishi, Minoru Ota, Naoki Maeda, Daisuke Kozuka, Noriko Fukuhara
Journal: Blood
Blood (2024) 144 (Supplement 1): 5108.
https://doi.org/10.1182/blood-2024-203198
Published: 2024
Journal Articles

Transcription Factor GATA2 Is Inevitable for the Survival and Proper Differentiation of Thymic Multipotent Progenitor Cells By Gene Expression Orchestration

Free
Sayaka Sano, Hiroki Kato, Yan Yan, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Tohru Fujiwara, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 1182.
https://doi.org/10.1182/blood-2023-178454
Published: 2023
Journal Articles

Survival and CNS Relapse in Patients with CD5-Positive Diffuse Large B-Cell Lymphoma: A Multi-Institutional Observational Study in Japan

Free
Yuma Nato, Kana Miyazaki, Dai Maruyama, Hiroyuki Takahashi, Kazutaka Sunami, Satsuki Murakami, Eiju Negoro, Yuri Miyazawa, Ilseung Choi, Takahiro Okada, Nobuyuki Takayama, Naoto Tomita, Shuji Momose, Yuto Kaneda, Masahiro Yoshida, Hiroshi Gomyo, Kohtaro Toyama, Momoko Nishikori, Akio Saito, Junji Hiraga, Taro Masunari, Naoki Takahashi, Junya Makiyama, Tomotaka Suzuki, Hiroko Tsunemine, Jun Takizawa, Takeharu Kato, Yasufumi Masaki, Noriko Fukuhara, Masataka Okamoto, Isao Tawara, Naoko Asano, Koichi Ohshima, Koji Izutsu, Koji Kato, Ritsuro Suzuki, Motoko Yamaguchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1762.
https://doi.org/10.1182/blood-2023-174647
Published: 2023
Journal Articles

Impact of Mogamulizumab-Containing Chemotherapy on HBV Reactivation in Patients with T-Cell Lymphoma: A Multicenter Retrospective Observational Study (PROACTIVE-MOGA)

Free
Kisato Nosaka, Shigeru Kusumoto, Yoshitaka Imaizumi, Hiroya Hashimoto, Junya Makiyama, Makoto Yoshimitsu, Takeharu Kato, Hidenori Sasaki, Youko Suehiro, Ki-Ryang Koh, Toyotaka Kawamata, Toshikazu Miyakawa, Yoshifusa Takatsuka, Takayuki Sato, Yuko Shirouchi, Koji Kato, Koji Izutsu, Tohru Murayama, Takehiro Higashi, Hiromi Iwasaki, Satoru Kosugi, Hitoji Uchiyama, Kunihiro Tsukasaki, Yusuke Yamashita, Fumiya Ogasawara, Emiko Sakaida, Takero Shindo, Kimikazu Yakushijin, Keiichi Akizuki, Ken-ichiro Etoh, Noriaki Kawano, Tetsuyuki Igarashi, Noriko Fukuhara, Nobuhiko Nakamura, Isao Yoshida, Nobuaki Nakano, Tomoharu Yoshizumi, Masashi Mizokami
Journal: Blood
Blood (2023) 142 (Supplement 1): 6192.
https://doi.org/10.1182/blood-2023-185878
Published: 2023
Journal Articles

Post-Hoc Analysis of the Final, Three-Year Follow-up Results of a Phase I/II Study on Tirabrutinib (ONO-4059) in Patients with Relapsed or Refractory Primary Central Nervous System Lymphoma

Free
Noriko Fukuhara, Yoshitaka Narita, Motoo Nagane, Kazuhiko Mishima, Yasuhito Terui, Yoshiki Arakawa, Hajime Yonezawa, Katsunori Asai, Kazuhiko Sugiyama, Naoki Shinojima, Arata Aoi, Ryo Nishikawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 4472.
https://doi.org/10.1182/blood-2023-180438
Published: 2023
Journal Articles

Hematopoietic Stem/Progenitor Cell Intrinsic SAM Synthesis Is Required to Prevent p53 Pathway Activation By Maintaining DNA Stability

Free
Eijiro Furukawa, Hiroki Kato, Sayaka Sano, Yan Yan, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Daisuke Saigusa, Tohru Fujiwara, Kazuhiko Igarashi, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 4049.
https://doi.org/10.1182/blood-2023-180384
Published: 2023
Journal Articles

Final Analysis of the Randomized Phase II/III Study of Standard R-CHOP Versus CHOP Combined with Dose-Dense Weekly Rituximab for DLBCL: JCOG0601

Free
Ken Ohmachi, Tomohiro Kinoshita, Dai Maruyama, Gakuto Ogawa, Yusuke Sano, Nobuhiko Yamauchi, Noriko Fukuhara, Toshiki Uchida, Kazuhito Yamamoto, Kana Miyazaki, Norifumi Tsukamoto, Shinsuke Iida, Isao Yoshida, Yasuhiro Suzuki, Yasufumi Masaki, Tohru Murayama, Yoshihiro Yakushijin, Youko Suehiro, Kisato Nosaka, Nobuaki Dobashi, Junya Kuroda, Wataru Munakata, Kiyoshi Ando, Kenichi Ishizawa, Michinori Ogura, Tadashi Yoshino, Tomomitsu Hotta, Kunihiro Tsukasaki, Kensei Tobinai, Hirokazu Nagai
Journal: Blood
Blood (2023) 142 (Supplement 1): 1724.
https://doi.org/10.1182/blood-2023-178551
Published: 2023
Journal Articles

Roles for Heme Synthesis in the Maintenance of Hematopoietic Stem and Progenitor Cells

Free
Yan Yan, Hiroki Kato, Sayaka Sano, Eijiro Furukawa, Daigo Michimata, Yuya Tanaka, Kazuki Sakurai, Koichi Onodera, Satoshi Ichikawa, Tohru Fujiwara, Yasushi Onishi, Noriko Fukuhara, Hisayuki Yokoyama, Hideo Harigae
Journal: Blood
Blood (2023) 142 (Supplement 1): 2682.
https://doi.org/10.1182/blood-2023-174202
Published: 2023
Journal Articles

The hepatic niche leads to aggressive natural killer cell leukemia proliferation through the transferrin–transferrin receptor 1 axis

Free
Kazuaki Kameda, Ryo Yanagiya, Yuji Miyatake, Joaquim Carreras, Hiroshi Higuchi, Hiromichi Murayama, Takashi Ishida, Asahi Ito, Shinsuke Iida, Noriko Fukuhara, Hideo Harigae, Yuki Fujioka, Naoto Takahashi, Hidenori Wada, Fumihiro Ishida, Hideyuki Nakazawa, Rei Ishihara, Yuki Murakami, Hiroyuki Tagawa, Tadashi Matsuura, So Nakagawa, Sadahiro Iwabuchi, Shinichi Hashimoto, Ken-Ichi Imadome, Naoya Nakamura, Kenichi Ishizawa, Yoshinobu Kanda, Kiyoshi Ando, Ai Kotani
Journal: Blood
Blood (2023) 142 (4): 352–364.
https://doi.org/10.1182/blood.2022018597
Published: 2023
Includes: Supplemental data