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Journal Articles

Optimizing establishment of high need pediatric Acute Myeloid Leukemia (AML) patient derived xenograft (PDX) models

Lana Kim, Max Rochette, Shivani Gollapudi, Courtney Pette, Michele Redell, Alexandra Stevens

Blood (2025) 146 (Supplement 1): 1515.

https://doi.org/10.1182/blood-2025-1515

Published: 2025

Journal Articles

Clinical and molecular characterization of pure erythroid leukemias and sarcomas driven by nfia::CBFA2T3

Blood (2025) 146 (Supplement 1): 3510.

https://doi.org/10.1182/blood-2025-3510

Published: 2025

Journal Articles

Update AML: Updated disease monitoring and treatment to enhance outcomes for pediatric AML (NCT07059975)

Joanna Yi, Alexandra Stevens, Shannon Conneely, Chelsea Vrana, Hana Paek, Susan Hilsenbeck, Eunji Jo, Matthew Willis, Julienne Brackett, Kevin Fisher, Michele Redell

Blood (2025) 146 (Supplement 1): 8248.

https://doi.org/10.1182/blood-2025-8248

Published: 2025

Journal Articles

Manual review of select hotspots may unmask clonal hematopoiesis variants at low levels in at-risk pediatric patients undergoing initial bone marrow sequencing

Fouad El-Dana, Tarek Elghetany, Michele Redell, Angshumoy Roy, Alison Bertuch, Joanna Yi, Kevin Fisher

Blood (2025) 146 (Supplement 1): 6709.

https://doi.org/10.1182/blood-2025-6709

Published: 2025

Journal Articles

Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Sara K. Silbert, Alexander W. Rankin, Chloe N. Hoang, Alexandra Semchenkova, Regina M. Myers, Elena Zerkalenkova, Hao-Wei Wang, Alexandra E. Kovach, Constance M. Yuan, Dana Delgado Colon, Loïc Vasseur, Alex Bataller, Samuel John, Kaylyn Utley Lyons, Barbara Friedes, Anna Alonso-Saladrigues, Hisham Abdel-Azim, Estelle Balducci, Ahmed Assim Aljudi, Marie Balsat, D. Nathan Biery, Aghiad Chamdin, Bill H. Chang, Raymund S. Cuevo, Barbara De Moerloose, David S. Dickens, Ulrich Duffner, Nicolas Duployez, Firas El Chaer, Michelle Ann Elliott, Gabriele Escherich, Sneha Fernandes, Mandi R. Fitzjohn, Zhubin Gahvari, Stephan A. Grupp, Rui Rochelle He, Cynthia Harrison, Christopher B. Hergott, Emily M. Hsieh, Annette S. Kim, Dennis J. Kuo, Daniel P. Larson, Benjamin J. Lee, Thibaut Leguay, R. Coleman Lindsley, Abhishek A. Mangaonkar, Kerstin Mezger, Holly L. Pacenta, Jing Pan, Marlie Provost, Latika Puri, Sunil S. Raikar, Armando Martinez, Isabella Bristol, Kyle Murphy, Lauren Reiman, Michele Redell, Kelly Reed, Gabrielle Roth-Guepin, Jeremy Rubinstein, Süreyya Savaşan, Kristian Schafernak, Alexandra Stevens, Aimee Talleur, Naomi Torres Carapia, Jacques Vargaftig, Anant Vatsayan, Matthias Wölfl, Liping Zhao, Susana Rives, Vanessa A. Fabrizio, Koji Sasaki, Ibrahim Aldoss, Nicolas Boissel, Susan R. Rheingold, Kara L. Davis, Sara Ghorashian, Elad Jacoby, Alexander Popov, Adam J. Lamble, Nirali N. Shah

Blood (2025) 146 (4): 437–455.

https://doi.org/10.1182/blood.2024026655

Published: 2025

Includes: Supplemental data

Journal Articles

Poor Outcomes Among Pediatric Non-Down Syndrome Acute Megakaryocytic Leukemia Patients Irrespective of Receipt of Hematopoietic Stem Cell Transplant

Gabriela Llaurador, Matthew Willis, Michele Redell, M Monica Gramatges, Swati Naik, Robert A. Krance, Erin E Doherty, Alexandra McLean Stevens

Blood (2022) 140 (Supplement 1): 10632–10633.

https://doi.org/10.1182/blood-2022-167487

Published: 2022

Journal Articles

Combining Atovaquone with Intensive Conventional Chemotherapy for Pediatric Acute Myeloid Leukemia (AML) Is Feasible and Well Tolerated

Blood (2021) 138 (Supplement 1): 2312.

https://doi.org/10.1182/blood-2021-146057

Published: 2021

Journal Articles

Gene Expression Analysis of CML Patients across the Age Spectrum

Blood (2021) 138 (Supplement 1): 1473.

https://doi.org/10.1182/blood-2021-148701

Published: 2021

Journal Articles

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-142270

Published: 2020

Journal Articles

Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Myeloid Leukemia in the Contemporary Era

Erin E Doherty, MD, Michele Redell, MD, Ghadir Sasa, MD, Khaled Yassine, MD, Tami D John, MD, John Craddock, Mengfen Wu, MS, Tao Wang, PhD, Caridad A. Martinez, MD, Robert A. Krance, MD, Swati Naik, MBBS

Blood (2019) 134 (Supplement_1): 2056.

https://doi.org/10.1182/blood-2019-131131

Published: 2019

Journal Articles

Targeting Activated Signaling Pathways for the Treatment of IKZF1 -Deleted B Lymphoblastic Leukemia

Rohit Gupta, BA, Jason H. Rogers, MS, Xin Long, PhD, Geraldo Medrano, BS, Jaime M. Reyes, BS, Michele Redell, MD PhD, Zachary T Ball, PhD, Margaret Goodell, PhD, Rachel E. Rau, MD

Blood (2019) 134 (Supplement_1): 3789.

https://doi.org/10.1182/blood-2019-127209

Published: 2019

Journal Articles

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Xin Long, PhD, Chris Man, PhD, Padmini Narayanan, PhD, Elizabeth Seashore, MD, Michele Redell, MD PhD

Blood (2019) 134 (Supplement_1): 3731.

https://doi.org/10.1182/blood-2019-129074

Published: 2019

Journal Articles

Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia

Pinar Ataca Atilla, MD, Haruko Tashiro, MD PhD, Mary Kathryn McKenna, PhD, Madhuwanti Srinivasan, Brian Wesley Simons, Alexandra McLean Stevens, MD PhD, Michele Redell, MD PhD, Maksim Mamonkin, PhD, Malcolm K. Brenner, MD PhD, Erden Atilla, MD

Blood (2019) 134 (Supplement_1): 3912.

https://doi.org/10.1182/blood-2019-127953

Published: 2019

Journal Articles

Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells

Blood (2018) 132 (Supplement 1): 4246.

https://doi.org/10.1182/blood-2018-99-119974

Published: 2018

Journal Articles

Signaling Responses to Stroma-Derived Soluble Factors Are Associated with Outcome and with Expression of Microenvironment-Related Genes in Pediatric AML

Padmini Narayanan, PhD, Yi-Cheng Wang, Chris Tsz-Kwong Man, PhD, Rhonda E. Ries, MA, Robert B Gerbing, MA, Soheil Meshinchi, MD PhD, Todd A Alonzo, PhD, Michele Redell, MD PhD

Blood (2018) 132 (Supplement 1): 1510.

https://doi.org/10.1182/blood-2018-99-118771

Published: 2018

Journal Articles

Atovaquone Demonstrates Single Agent Activity and an Additive Effect in Combination with Cytotoxic Chemotherapy (Cytarabine and Daunorubicin) in AML

Alexandra McLean Stevens, MD, Jaime Omar Munoz, Michael Krueger, Terzah M. Horton, MD PhD, Michele Redell, MD PhD

Blood (2017) 130 (Supplement 1): 3899.

https://doi.org/10.1182/blood.V130.Suppl_1.3899.3899

Published: 2017

Journal Articles

Select Peripheral Blood Cytokine Levels Are Associated with Survival in Pediatric Acute Myeloid Leukemia

Alexandra McLean Stevens, MD, Terzah M. Horton, MD PhD, Michele Redell, MD PhD

Blood (2017) 130 (Supplement 1): 2690.

https://doi.org/10.1182/blood.V130.Suppl_1.2690.2690

Published: 2017

Journal Articles

Wild-Type and Mutant C-Kit Activation of Stat3α Contribute to Leukemogenesis through Distinct Effects on Myeloid Cell Proliferation and Resistance to Apoptosis

Michele Redell, MD, PhD, Marcos J. Ruiz, David John Tweardy, MD

Blood (2008) 112 (11): 5317.

https://doi.org/10.1182/blood.V112.11.5317.5317

Published: 2008

Journal Articles

Stat3β Promotes Basal Granulopoiesis and Inhibits Emergency Granulopoiesis, While Stat3α Inhibits Basal Granulopoiesis and Promotes Emergency Granulopoiesis

Michele Redell, MD, PhD, S. Wen-Wen Chen, MD, Marcos J. Ruiz, David J. Tweardy, MD

Blood (2008) 112 (11): 3871.

https://doi.org/10.1182/blood.V112.11.3871.3871

Published: 2008

Journal Articles

Overexpression of Stat3α, but Not Statβ, in Myeloid Cells Results in Neutrophil Expansion through Reduced Apoptosis and Modulation of a Unique Set of Apoptosis Pathway Genes.

Michele Redell, MD, PhD, Anna Tsimelzon, PhD, Susan G. Hilsenbeck, PhD, David John Tweardy, MD

Blood (2006) 108 (11): 1147.

https://doi.org/10.1182/blood.V108.11.1147.1147

Published: 2006

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Optimizing establishment of high need pediatric Acute Myeloid Leukemia (AML) patient derived xenograft (PDX) models

Clinical and molecular characterization of pure erythroid leukemias and sarcomas driven by nfia::CBFA2T3

Update AML: Updated disease monitoring and treatment to enhance outcomes for pediatric AML (NCT07059975)

Manual review of select hotspots may unmask clonal hematopoiesis variants at low levels in at-risk pediatric patients undergoing initial bone marrow sequencing

Project EVOLVE: an international analysis of postimmunotherapy lineage switch, an emergent form of relapse in leukemia

Poor Outcomes Among Pediatric Non-Down Syndrome Acute Megakaryocytic Leukemia Patients Irrespective of Receipt of Hematopoietic Stem Cell Transplant

Combining Atovaquone with Intensive Conventional Chemotherapy for Pediatric Acute Myeloid Leukemia (AML) Is Feasible and Well Tolerated

Gene Expression Analysis of CML Patients across the Age Spectrum

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Myeloid Leukemia in the Contemporary Era

Targeting Activated Signaling Pathways for the Treatment of IKZF1 -Deleted B Lymphoblastic Leukemia

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Enhancing the Effect of CLL-1 CAR T Cells with Interleukin-15 for Treatment of Acute Myeloid Leukemia

Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells

Signaling Responses to Stroma-Derived Soluble Factors Are Associated with Outcome and with Expression of Microenvironment-Related Genes in Pediatric AML

Atovaquone Demonstrates Single Agent Activity and an Additive Effect in Combination with Cytotoxic Chemotherapy (Cytarabine and Daunorubicin) in AML

Select Peripheral Blood Cytokine Levels Are Associated with Survival in Pediatric Acute Myeloid Leukemia

Wild-Type and Mutant C-Kit Activation of Stat3α Contribute to Leukemogenesis through Distinct Effects on Myeloid Cell Proliferation and Resistance to Apoptosis

Stat3β Promotes Basal Granulopoiesis and Inhibits Emergency Granulopoiesis, While Stat3α Inhibits Basal Granulopoiesis and Promotes Emergency Granulopoiesis

Overexpression of Stat3α, but Not Statβ, in Myeloid Cells Results in Neutrophil Expansion through Reduced Apoptosis and Modulation of a Unique Set of Apoptosis Pathway Genes.

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