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Michele Lambert
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Journal Articles

Treatment strategies and outcomes in pediatric patients with immune thrombocytopenia (ITP) undergoing surgical procedures: A multicenter study

Free
Matthew Ross, Lia Phillips, Kristyn Pierce, Danielle Charland, Nour El Haouzi, Praharsha Konde, Matthew Meuler, Caitlin Montcrieff, Sara Ukropina, Karen Wang, Rachael Grace, Robert Klaassen, Michele Lambert, Thomas Pincez, Allison Remiker, Kirsty Hillier
Journal: Blood
Blood (2025) 146 (Supplement 1): 3046.
https://doi.org/10.1182/blood-2025-3046
Published: 2025
Journal Articles

Systematic review on the diagnostic evaluation of pediatric evans syndrome

Free
Megan Askew, Ashley Geerlinks, Neeti Luke, Thomas Pincez, Maritza Ruiz, Prachi Sharma, Sasidhar Goteti, Shilpa Nataraj, Monia Marchetti, Rachael Grace, Michele Lambert, Kirsty Hillier
Journal: Blood
Blood (2025) 146 (Supplement 1): 6172.
https://doi.org/10.1182/blood-2025-6172
Published: 2025
Journal Articles

End-of-study results from the ICON3 pines trial, a phase 3, randomized trial of eltrombopag vs. standard first-line treatment for newly diagnosed immune thrombocytopenia in children

Free
Kristin Shimano, Amanda Grimes, Melissa Rose, Shipra Kaicker, Sanjay Shah, Michael Briones, Elizabeth Gunn, Taizo Nakano, Jeffrey Lebensburger, Michele Lambert, Stephanie Fritch Lilla, Rohith Jesudas, Cathy Lee-Miller, Alexis Thompson, Rukhmi Bhat, Stacey Rifkin-Zenenberg, Suvankar Majumdar, Manpreet Kochhar, Shelley Crary, Kerry Hege, Jennifer Rothman, James Ford, Joshua Bies, Tung Wynn, Loan Hsieh, Maritza Ruiz, Bogdan Dinu, Julia Wong, Pei-Chi Kao, Staci Arnold, Carolyn Bennett, Jenny Despotovic, Robert Klaassen, Ellis Neufeld, Cindy Neunert, Wendy London, Rachael Grace
Journal: Blood
Blood (2025) 146 (Supplement 1): 738.
https://doi.org/10.1182/blood-2025-738
Published: 2025
Journal Articles

Germline genetic testing uncovers a high frequency of inborn error of immunity diagnoses in children with single and multi-lineage immune cytopenias in a large US cohort

Free
Emily Harris, Thomas Pincez, Kirsty Hillier, Yi-Lee Ting, Jennifer MacWhirter - DiRaimo, Hannah Helber, Candelaria O'Farrell, Estelle Lecluze, Taylor Kim, Rachael Grace, Michael Scheurer, Rebecca Hale, Kristin Shimano, Diane Nugent, Ellis Neufeld, Craig Platt, Michele Lambert, Amanda Grimes, Shipra Kaicker
Journal: Blood
Blood (2025) 146 (Supplement 1): 630.
https://doi.org/10.1182/blood-2025-630
Published: 2025
Journal Articles

Reproductive health in patients with primary immune thrombocytopenia (ITP) receiving rilzabrutinib: A subgroup analysis from the Phase 3 LUNA3 multicenter study

Free
Michele Lambert, Nicola Cooper, Maria Cristina Pascual Izquierdo, Elisa Lucchini, Sylvain Audia, Huafang Wang, Yoshitaka Miyakawa, Meredith Foster, Maria Belen Rodriguez, Ahmed Daak, David Kuter
Journal: Blood
Blood (2025) 146 (Supplement 1): 3027.
https://doi.org/10.1182/blood-2025-3027
Published: 2025
Journal Articles

Activating STIM1 mutations drive the development of myelofibrosis

Free
Molly Brakhane, Vittorio Abbonante, Angelo Laranjeira, Christian Di Buduo, Brooke Sadler, Katrina Ashworth, Tim Kong, Christopher Letson, Fan He, Mary Fulbright, Joshua Siner, Dong Chen, Regina Clemens, Elena Pegoraro, Michele Lambert, Kandace Gollomp, Jorge Di Paola, Alessandra Balduini, Stephen Oh
Journal: Blood
Blood (2025) 146 (Supplement 1): 5528.
https://doi.org/10.1182/blood-2025-5528
Published: 2025
Journal Articles

Comparison of Bleeding Tools in a Cohort of Pediatric Patients with ITP: Data from the Pediatric ITP Consortium of North America ICON1 Study

Free
Breakey R. Vicky, MD MD FRCPC, Rachael F Grace, MD, Carolyn M. Bennett, Jenny M. Despotovic, DO, MS, Jennifer A Rothman, MD, Yves D. Pastore, MD, Ellis J Neufeld, MD PhD, Robert J. Klaassen, MD, Michele Lambert, MD, James B. Bussel, MD, George R. Buchanan, MD, Melissa J. Rose, DO, Amy E. Geddis, MD PhD, Kristin Shimano, MD, Kerry Hege, MD, Kristina M. Haley, DO, Adonis Lorenzana, MD, Alexis A. Thompson, MD MPH, Michael Jeng, MD, Shelley E. Crary, MD MSCS, Michelle Neier, MD, Travis Brown, Peter Forbes, BS, Cindy Neunert, MD
Journal: Blood
Blood (2016) 128 (22): 4752.
https://doi.org/10.1182/blood.V128.22.4752.4752
Published: 2016
Journal Articles

Clinical Characteristics and Quality of Life of Children with ITP Starting Second Line Treatments: Data from the ITP Consortium of North America ICON1 Study

Free
Rachael F Grace, MD, Robert J. Klaassen, MD, Jennifer A Rothman, MD, Kerry Hege, MD, Ellis J Neufeld, MD PhD, Carolyn M. Bennett, Michele Lambert, MD, Vicky R. Breakey, BSc, MD MD FRCPC, James B. Bussel, MD, George R. Buchanan, MD, Melissa J. Rose, DO, Amy Geddis, MD PhD, Kristin Shimano, MD, Kristina M. Haley, DO, Adonis Lorenzana, MD, Cindy Neunert, MD, Alexis A. Thompson, MD MPH, Yves D. Pastore, MD, Michael Jeng, MD, Shelley E. Crary, MD MSCS, Michelle Neier, MD, Travis Brown, Peter Forbes, BS, Jenny M. Despotovic, DO, MS
Journal: Blood
Blood (2016) 128 (22): 249.
https://doi.org/10.1182/blood.V128.22.249.249
Published: 2016
Journal Articles

Platelet Factor 4 (PF4) Is Selectively Recycled During Megakaryopoiesis

Free
Michele Lambert, MD, Liqing Xiao, PhD, Ronghua Meng, PhD, Michael S. Marks, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2012) 120 (21): 388.
https://doi.org/10.1182/blood.V120.21.388.388
Published: 2012
Journal Articles

2-O, 3-O-Desulfated Heparin (ODSH) Mitigates Chemotherapy-Induced Thrombocytopenia (CIT) by Blocking the Negative Paracrine Effect of Platelet Factor 4 (PF4) On Megakaryopoiesis

Free
Michele Lambert, MD, Samriddhi S Sharma, Liqing Xiao, PhD, Stephen Marcus, MD, Mortimer Poncz, MD
Journal: Blood
Blood (2012) 120 (21): 386.
https://doi.org/10.1182/blood.V120.21.386.386
Published: 2012
Journal Articles

Platelet Factor 4 (PF4) Causes Cell Cycle Arrest in Megakaryocytes (Megs) by Inactivating CDC2 (CDK1) and CDK2

Free
Liqing Xiao, PhD, Mortimer Poncz, MD, Michele Lambert, MD
Journal: Blood
Blood (2012) 120 (21): 1238.
https://doi.org/10.1182/blood.V120.21.1238.1238
Published: 2012
Journal Articles

Tissue-Specific Transgene Expression in Induced Pluripotent Stem (iPS) Cell-Derived Megakaryocytes: Correction of Glanzmann Thrombasthenia (GT)

Free
Spencer K. Sullivan, MD, Jason A. Mills, PhD, Li Zhai, MD, Prasuna Paluru, MS, Karen Vo, Michele Lambert, MD, Sevasti B. Koukouritaki, PhD, Juan Fang, MD, David A. Wilcox, PhD, Deborah L. French, PhD, Mortimer Poncz, MD, Paul Gadue, PhD
Journal: Blood
Blood (2012) 120 (21): 387.
https://doi.org/10.1182/blood.V120.21.387.387
Published: 2012
Journal Articles

A Novel Mutation in MPL (Y252H) Results in Increased Thrombopoietin Sensitivity and Moderate Thrombocytosis in a Pediatric Patient with Essential Thrombocytosis

Free
Michele Lambert, MD, Jing Jiang, Wei Tong
Journal: Blood
Blood (2011) 118 (21): 2817.
https://doi.org/10.1182/blood.V118.21.2817.2817
Published: 2011
Journal Articles

Platelet Factor 4 (PF4) Levels Are Inversely Correlated with Steady-State Platelet Counts and with Nadir Counts in Chemotherapy-Induced Thrombocytopenia (CIT),

Free
Michele Lambert, MD, Alisa Reznikov, Liqing Xiao, PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2011) 118 (21): 3527.
https://doi.org/10.1182/blood.V118.21.3527.3527
Published: 2011
Journal Articles

Targeted Gene Correction of Glanzmann Thrombasthenia Induced Pluripotent Stem Cells Restores Surface Expression and Fibrinogen Binding of Integrin αIIbβ3,

Free
Spencer Sullivan, MD, Jason A. Mills, PhD, Li Zhai, MD, Prasuna Paluru, MS, Guohua Zhao, PhD, Lin Lu, PhD, Michele Lambert, MD, Deborah L. French, PhD, Mortimer Poncz, MD, Paul Gadue, PhD
Journal: Blood
Blood (2011) 118 (21): 4173.
https://doi.org/10.1182/blood.V118.21.4173.4173
Published: 2011
Journal Articles

Response to Steroids Predicts Response to Rituximab In Pediatric Chronic Immune Thrombocytopenia.

Free
Rachael F. Grace, MD, Carolyn M. Bennett, MD, MS, A. Kim Ritchey, MD, Michael R. Jeng, MD, Courtney Thornburg, MD, MS, Michele Lambert, MD, Michelle Neier, MD, Michael Recht, MD, PhD, Manjusha Kumar, MD, Victor Blanchette, MD, Robert Klaassen, MD, FRCP, George R. Buchanan, MD, Margaret A. Heisel Kurth, MD, Diane J. Nugent, MD, Alexis A. Thompson, MD, MPH, Kimo Stine, MD, Leslie A. Kalish, ScD, Ellis J. Neufeld, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3681.
https://doi.org/10.1182/blood.V116.21.3681.3681
Published: 2010
Journal Articles

Platelet Factor 4 Levels Inversely Correlate with Platelet Transfusion Needs In Pediatric Patients Treated for Standard Risk Acute Lymphoblastic Leukemia

Free
Michele Lambert, MD, Alisa Reznikov, Yvonne Nguyen, Lubica Rauova, Mortimer Poncz, MD
Journal: Blood
Blood (2010) 116 (21): 725.
https://doi.org/10.1182/blood.V116.21.725.725
Published: 2010