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Izidore S. Lossos
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Journal Articles

PARP1 facilitates transcriptional activity and stability of the BCL6 protein and is a therapeutic target in BCL6 expressing lymphomas

Free
XiaoQing Lu, Carolina Bañuelos, Lucas Caeiro, Poonam Yadav, Jessica Bouviere, Xiaoyu Jiang, Zhang Yu, Daniel Bilbao, Jennifer Chapman, Ramiro Verdun, Izidore S. Lossos
Journal: Blood
Blood (2025) 146 (Supplement 1): 5034.
https://doi.org/10.1182/blood-2025-5034
Published: 2025
Journal Articles

Treatment patterns in patients aged 80+ years with LBCL: Propensity score analysis reveals comparable outcomes between R-CHOP and R-mini-CHOP

Free
Prokop Vodicka, Patrick Reagan, Michal Masar, Izidore S. Lossos, Katerina Benesova, Eric Mou, Kamila Polgarova, David Jaye, Diana Malarikova, Chijioke Nze, Jan Koren, Dilan Patel, Josef Karban, Peter Martin, Jana Salkova, Andrew Feldman, Jitka Dlouha, Jonathon Cohen, Petra Blahovcova, Raphael Mwangi, Thomas Habermann, Radek Jaksa, Matthew Maurer, Magdalena Klanova, Grzegorz Nowakowski, Pavel Klener, Jonathan Friedberg, Christopher Flowers, Marek Trneny, James Cerhan
Journal: Blood
Blood (2025) 146 (Supplement 1): 5448.
https://doi.org/10.1182/blood-2025-5448
Published: 2025
Journal Articles

FLP-R: A clinical prediction model for follicular lymphoma Prognosis in the Relapsed/refractory setting

Free
Matthew Maurer, Melissa Larson, Urshila Durani, Mazie Tsang, Eric Mou, Jonathon Cohen, Jonathan Day, Jennifer Bøgh Jørgensen, Christopher Strouse, Jose Villasboas Bisneto, Andrew Feldman, Sergei Syrbu, Richard Burack, Dai Chihara, Elliot Cahn, David Russler-Germain, Stephen Ansell, Yucai Wang, Loretta Nastoupil, Peter Martin, Izidore S. Lossos, Jean Koff, Thomas Habermann, Tarec Christoffer El-Galaly, James Cerhan, Christopher Flowers, Brian Link, Carla Casulo
Journal: Blood
Blood (2025) 146 (Supplement 1): 5354.
https://doi.org/10.1182/blood-2025-5354
Published: 2025
Journal Articles

Multi-center real world analysis of treatment outcomes of non-COVALENT btki, pirtobrutinib, in patients with COVALENT btki relapsed/refracdtory Mantle Cell Lymphoma

Free
Paolo Lopedote, Adrienne Nedved, Lu Chen, Marcus Watkins, Arian Roua, Muhamad Alhaj Moustafa, Seyi Abidoye, Yun Choi, Georgios Pongas, Tony Zhuang, Jean Clement, Megan Searssmith, Laura Sun, Hannah Willis, Brad Kahl, David Bond, Javier Munoz, Izidore S. Lossos, Craig Portell, Michael Wang, Nilanjan Ghosh, Jonathon Cohen, Peter Martin, Jeremy Abramson, Anne Beaven, Patrick Reagan, Daniel Ermann, Taylor Brooks, Ashlee Joseph, Nazila Shafagati, Daniel McLoughlin, Kira Rosenlind, Brian Hill, Nina Wagner-Johnston, Anita Kumar, Umar Farooq, Reem Karmali, Tanaya Shree, Matthew Lunning, Stacy Pak, Alexey Danilov, Yucai Wang, Tycel Phillips
Journal: Blood
Blood (2025) 146 (Supplement 1): 5351.
https://doi.org/10.1182/blood-2025-5351
Published: 2025
Journal Articles

Prognostic impact of diagnosis-to-treatment interval in follicular lymphoma patients treated with immunochemotherapy: Evidence from an international cohort with independent validation

Free
Prokop Vodicka, Tarec Christoffer El-Galaly, Vit Prochazka, Christopher Flowers, Diego Villa, Caroline Dietrich, Herve Ghesquieres, Michael Roost Clausen, Robert Kridel, Chan Cheah, Eliza Hawkes, Björn Wahlin, Maher Gandhi, Melissa Larson, Elliot Cahn, Jonathan Friedberg, Peter Martin, Dai Chihara, Jonathon Cohen, Thomas Habermann, Carla Casulo, Yucai Wang, Peter Brown, Eric Mou, David Belada, Andrea Janikova, Heidi Mocikova, Richard Burack, Izidore S. Lossos, Brad Kahl, Karin Ekstroem Smedby, Laurie Sehn, Marek Trneny, James Cerhan, Matthew Maurer
Journal: Blood
Blood (2025) 146 (Supplement 1): 3601.
https://doi.org/10.1182/blood-2025-3601
Published: 2025
Journal Articles

Survival differences in metropolitan versus nonmetropolitan/rural counties in the US: An analysis according to rural-urban continuum codes (RUCC) in the lymphoma epidemiology of outcomes (LEO) study cohort

Free
Mario Ballerini, Melissa Larson, James Foran, Matthew Bryant Howren, Michelle Hildebrandt, Pamela Allen, Shaun Riska, Matthew Maurer, Susan Slager, Andrew Feldman, David Jaye, Thomas Habermann, Jonathon Cohen, Brad Kahl, Peter Martin, Izidore S. Lossos, Jonathan Friedberg, Brian Link, Eric Mou, Chijioke Nze, Carrie Thompson, Annalynn Williams, Kathleen Yost, Christopher Flowers, James Cerhan
Journal: Blood
Blood (2025) 146 (Supplement 1): 6324.
https://doi.org/10.1182/blood-2025-6324
Published: 2025
Journal Articles

Patterns of care and outcomes in patients with large B-cell lymphoma not treated with full-dose anthracycline regimens: Outcome analysis from the lymphoma epidemiology of outcomes (LEO) prospective cohort study

Free
Patrick Reagan, Raphael Mwangi, Jean Koff, Yucai Wang, Dai Chihara, Arushi Khurana, Eric Mou, Loretta Nastoupil, Umar Farooq, Ayo Falade, Chijioke Nze, Tanner Reicks, Jonathon Cohen, Andrew Feldman, David Jaye, Grzegorz Nowakowski, Peter Martin, Brad Kahl, Thomas Habermann, Izidore S. Lossos, Matthew Maurer, Christopher Flowers, James Cerhan
Journal: Blood
Blood (2025) 146 (Supplement 1): 6312.
https://doi.org/10.1182/blood-2025-6312
Published: 2025
Journal Articles

A genetic comparison of epstein-barr virus-associated polymorphic lymphoproliferative disorder and diffuse large B cell lymphoma

Free
Jennifer Chapman, Evgeniia Alekseeva, Anna Tarasova, Alexander Nesmelov, Anastasiia Shvyrkova, Lizzie Sheehan, Ella Yakir, Kamilia Moalem, Ekaterina Postovalova, Nikita Kotlov, Alexander Bagaev, Nathan Fowler, Izidore S. Lossos
Journal: Blood
Blood (2025) 146 (Supplement 1): 1776.
https://doi.org/10.1182/blood-2025-1776
Published: 2025
Journal Articles

Genomic and transcriptomic landscape of extranodal marginal zone lymphoma

Free
Izidore S. Lossos, Leo Biral, Devang Thakkar, Kikkeri N Naresh, Sarah Ondrejka, Eric Hsi, Mina Xu, Jean Koff, David Jaye, Peter Nørgaard, Marie Fredslund Breinholt, Rebecca Leeman-Neill, Jennifer Shingleton, Lanie Happ, Cassandra Love, Emily F. Mason, Abner Louissaint, Choon Kiat Ong, Chee Leong Cheng, Raju Pillai, Mette Pedersen, C. Cameron Yin, Rex Au-Yeung, Marja-Liisa Karjalainen-Lindsberg, Amy Chadburn, Matthew McKinney, Payal Sojitra, Andrew Evans, Magdalena Czader, Yan Jiong, Sandeep Dave, Jennifer Chapman
Journal: Blood
Blood (2025) 146 (Supplement 1): 1761.
https://doi.org/10.1182/blood-2025-1761
Published: 2025
Journal Articles

Predictive performance of the LEO comorbidity index in patients aged 80+ years with large B-cell lymphoma

Free
Prokop Vodicka, Michal Masar, Carrie Thompson, Katerina Benesova, Izidore S. Lossos, Diana Malarikova, Annalynn Williams, Kamila Polgarova, Chijioke Nze, Jan Koren, Jonathon Cohen, Jana Salkova, Andrew Feldman, Josef Karban, Eric Mou, Petra Kovarikova, Elliot Cahn, Eva Konirova, Peter Martin, Jitka Dlouha, Mazie Tsang, Dilan Patel, Petra Blahovcova, Patrick Reagan, David Jaye, Magdalena Klanova, Jonathan Friedberg, Christopher Flowers, Pavel Klener, Matthew Maurer, Thomas Habermann, Marek Trneny, James Cerhan
Journal: Blood
Blood (2025) 146 (Supplement 1): 2741.
https://doi.org/10.1182/blood-2025-2741
Published: 2025
Journal Articles

Age-stratified prognostic performance of patient- vs disease-related IPI factors in large B-cell lymphoma

Free
Prokop Vodicka, Matthew Maurer, Pavel Klener, George Cholack, Vit Prochazka, Yucai Wang, David Belada, Christopher Flowers, David Salek, Izidore S. Lossos, Heidi Mocikova, Andrew Feldman, Juraj Ďuraš, Jonathon Cohen, Katerina Steinerova, Carla Casulo, Jan Pirnos, Brad Kahl, Kamila Polgarova, Eric Mou, Andrea Janikova, Peter Martin, Alice Sykorova, Ales Obr, David Jaye, Vit Campr, Diana Malarikova, Shaun Riska, Michal Kascak, Alexandra Suri, Chijioke Nze, Jozef Michalka, Radek Jaksa, Grzegorz Nowakowski, Jitka Dlouha, Petra Blahovcova, Thomas Habermann, Katerina Benesova, James Cerhan, Marek Trneny
Journal: Blood
Blood (2025) 146 (Supplement 1): 4516.
https://doi.org/10.1182/blood-2025-4516
Published: 2025
Journal Articles

FLIPI24 as a prognostic model in marginal zone lymphoma: Results from an international multi-cohort analysis

Free
Prokop Vodicka, Matthew Maurer, Michal Masar, Yucai Wang, Andrea Janikova, Izidore S. Lossos, David Belada, Jonathon Cohen, Ales Obr, Eric Mou, Heidi Mocikova, Carla Casulo, Juraj Ďuraš, Chijioke Nze, Katerina Steinerova, Dilan Patel, Josef Karban, Peter Martin, David Salek, Andrew Feldman, Alice Sykorova, Elliot Cahn, Magdalena Klanova, Vit Campr, David Jaye, Jozef Michalka, Pavla Stepankova, Sergei Syrbu, Samuel Hricko, Alexandra Suri, Melissa Larson, Radek Jaksa, Jitka Dlouha, Thomas Habermann, Petra Blahovcova, Christopher Flowers, Pavel Klener, Vit Prochazka, James Cerhan, Marek Trneny
Journal: Blood
Blood (2025) 146 (Supplement 1): 1826.
https://doi.org/10.1182/blood-2025-1826
Published: 2025
Journal Articles

Long-term follow-up with sustained progression-free survival (PFS) benefit after subcutaneous (SC) mosunetuzumab in combination with polatuzumab vedotin compared with rituximab plus polatuzumab vedotin in patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma

Free
Nilanjan Ghosh, Julio Chavez, Mariana Bastos-Oreiro, Catherine Diefenbach, Izidore S. Lossos, Nirav Shah, Sarit Assouline, Adam Olszewski, Seema Naik, Song Pham, Michael C. Wei, Connie L. Batlevi, Iris To, Wahib S. Ead, Sneha Makadia, Elicia Peneul, Elizabeth Budde
Journal: Blood
Blood (2025) 146 (Supplement 1): 1020.
https://doi.org/10.1182/blood-2025-1020
Published: 2025
Journal Articles

Shorter diagnosis to treatment interval is associated with poor prognosis in patients with peripheral T-cell lymphoma: Analysis from the LEO and MER cohorts

Free
Neha Mehta-Shah, Melissa Larson, Eric Mou, Pamela Allen, N. Nora Bennani, Danielle Wallace, Luis Malpica, Peter Martin, Jonathon Cohen, Thomas Habermann, Yucai Wang, Chijioke Nze, Izidore S. Lossos, Georgios Pongas, Thomas Witzig, Sergei Syrbu, David Jaye, Loretta Nastoupil, Christopher Flowers, James Cerhan, Andrew Feldman, Jia Ruan, Matthew Maurer
Journal: Blood
Blood (2025) 146 (Supplement 1): 5439.
https://doi.org/10.1182/blood-2025-5439
Published: 2025
Journal Articles

Outcomes of T-cell/histocyte-rich large B-cell lymphoma (THRLBCL): An international LEO/MER and NiHiL collaborative study

Free
Juan Alderuccio, Prokop Vodička, Jean Koff, Andrea Janikova, Matthew Maurer, Katerina Benesova, Heidi Mocikova, Peter Martin, Katerina Steinerova, Dilan Patel, David Belada, James Cerhan, Juraj Ďuraš, Vit Prochazka, Jonathon Cohen, David Salek, Thomas Habermann, Jan Koren, Melissa Larson, Andrew Feldman, Alexandra Suri, Patrick Reagan, Alice Sykorova, Jozef Michalka, Diana Malarikova, Yucai Wang, David Jaye, Zuzana Prouzova, Petra Blahovcova, Vit Campr, Eric Mou, Christopher Flowers, Izidore S. Lossos, Jonathan Friedberg, Grzegorz Nowakowski, Dai Chihara, Marek Trneny
Journal: Blood
Blood (2025) 146 (Supplement 1): 898.
https://doi.org/10.1182/blood-2025-898
Published: 2025
Journal Articles

Survival difference among patients with large B-cell lymphoma (LBCL)  based on first-line clinical trial participation: A multi-institutional analysis of 8 academic institutions in the lymphoma epidemiology of outcomes (LEO) cohort

Free
Chijioke Nze, Clark Andersen, Matthew Maurer, Melissa Larson, Jean Koff, Jonathon Cohen, Thomas Habermann, Jonathan Friedberg, Izidore S. Lossos, Peter Martin, Brad Kahl, David Jaye, Andrew Feldman, Carrie Thompson, James Cerhan, Christopher Flowers
Journal: Blood
Blood (2025) 146 (Supplement 1): 895.
https://doi.org/10.1182/blood-2025-895
Published: 2025
Journal Articles

Fixed-duration intravenous mosunetuzumab plus polatuzumab vedotin combination therapy continues to demonstrate durable responses in patients with large B-cell lymphoma: 3-year follow-up from a Phase Ib/II study

Free
Manali Kamdar, Julio Chavez, Adam Olszewski, Sarit Assouline, Izidore S. Lossos, Catherine Diefenbach, Dipenkumar Modi, Waleed Sabry, Seema Naik, Amitkumar Mehta, Sneha Makadia, Song Pham, Elicia Peneul, Hao Wu, Wahib S. Ead, Iris To, Dennis J. Houston, Connie Lee Batlevi, Elizabeth Budde
Journal: Blood
Blood (2025) 146 (Supplement 1): 3735.
https://doi.org/10.1182/blood-2025-3735
Published: 2025
Journal Articles

Loss of p53 enhances LMO2 induced transdifferentiation of  B-cells to T-cell acute lymphoblastic leukemia

Free
Izidore S. Lossos, Shlomzion Aumann, Andrew Gentles, Francisco Vega, Carolina Vicente-Dueñas, Hsuan-Ting Huang, Raymond Terryn, Sandro Satta, Brooks Benard, Ramiro Verdun, Isidro Sanchez-Garcia, Daniel Bilbao
Journal: Blood
Blood (2025) 146 (Supplement 1): 142.
https://doi.org/10.1182/blood-2025-142
Published: 2025
Journal Articles

Optimizing risk stratification in patients aged 80+ years with large B-cell lymphoma: Comparison of prognostic indices in three pooled international cohorts

Free
Prokop Vodicka, Yucai Wang, Katerina Benesova, Patrick Reagan, David Salek, Izidore S. Lossos, Vit Prochazka, Jean Koff, Alice Sykorova, Eric Mou, Heidi Mocikova, Andrew Feldman, Zuzana Prouzova, Brad Kahl, Juraj Ďuraš, Mazie Tsang, Katerina Steinerova, Chijioke Nze, Diana Malarikova, Raphael Mwangi, Andrea Janikova, Arushi Khurana, Jan Galko, Peter Martin, Kamila Polgarova, Sergei Syrbu, Jan Koren, Ales Obr, Jonathan Friedberg, David Belada, Michal Kascak, Jonathon Cohen, Michal Masar, Alexandra Suri, Grzegorz Nowakowski, Samuel Hricko, Andrea Hrušková, Christopher Flowers, Veronika Bergerova, Petra Blahovcova, Matthew Maurer, Jozef Michalka, Vit Campr, Thomas Habermann, Pavel Klener, James Cerhan, Marek Trneny
Journal: Blood
Blood (2025) 146 (Supplement 1): 786.
https://doi.org/10.1182/blood-2025-786
Published: 2025
Journal Articles

Novel immune gene expression signature risk-stratifies Mantle Cell Lymphoma outcomes independent of TP53 status

Free
Jean Koff, Veronica Russell, Rachel Kositsky, David Jaye, Michael Churnetski, Katelin Baird, Colin O'Leary, Christopher Flowers, Sirpa Leppä, Shaoying Li, Jessie Xu, Mette Pedersen, Anne Ortved Gang, Kikkeri N Naresh, Rex Au-Yeung, Jennifer Chapman, Amy Chadburn, Izidore S. Lossos, Sarah Ondrejka, Abner Louissaint, Eric Tse, Cassandra Love, Devang Thakkar, Clayton Parker, Choon Kiat Ong, Andrew Evans, Emily F. Mason, Yan Jiong, Magdalena Czader, Andrew Evens, Dina Soliman, Yuri Fedoriw, Sandeep Dave, Jonathon Cohen
Journal: Blood
Blood (2025) 146 (Supplement 1): 352.
https://doi.org/10.1182/blood-2025-352
Published: 2025