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Journal Articles

Durable efficacy of lenzilumab plus azacitidine in newly diagnosed proliferative CMML patients: Interim analysis after four years of study commencement

Free
Devendra Hiwase, David Ross, David Yeung, Agnes Yong, Steven Lane, Anna Brown, Chun Yew Fong, Timothy Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2025) 146 (Supplement 1): 3855.
https://doi.org/10.1182/blood-2025-3855
Published: 2025
Journal Articles

Subgroup analyses from the randomized, Phase 3 VERONA study of venetoclax with azacitidine (Ven+Aza) versus placebo with azacitidine (Pbo+Aza) in patients with treatment-naïve, intermediate and higher-risk Myelodysplastic Syndromes (HR MDS)

Free
Guillermo Garcia-Manero, Uwe Platzbecker, Pierre Fenaux, Gail Roboz, Chun Yew Fong, Marek Hus, Robert Delage, Andrew Brunner, Je-Hwan Lee, Mehmet Turgut, Dominiek Mazure, Yin-Hsun Feng, Yasushi Miyazaki, Zdeněk Kořístek, Sophie Salazar, Stefania Paolini, Maria Diez-Campelo, David Lavie, Dominic Culligan, Grace Ku, Zhijian Xiao, Fang Fang, Maggie Headley, Jalaja Potluri, Amer Zeidan, Jacqueline Garcia
Journal: Blood
Blood (2025) 146 (Supplement 1): 235.
https://doi.org/10.1182/blood-2025-235
Published: 2025
Journal Articles

Unravelling the epigenetic drivers of chip – MDS/CMML – AML progression through novel methylation-sensitive regulatory elements

Free
Yanjing Liu, Li Chai, Devendra Hiwase, David Ross, David Yeung, Agnes Yong, Steven Lane, Anna Brown, Chun Yew Fong, Timothy Hughes, John Reynolds, Daniel Thomas, Daniel Tenen, Mahmoud Bassal
Journal: Blood
Blood (2025) 146 (Supplement 1): 3231.
https://doi.org/10.1182/blood-2025-3231
Published: 2025
Journal Articles

Trial in progress: A Phase IIb randomized clinical trial combining oral azacitidine and vididencel, a novel immunotherapy, for post-remission / maintenance therapy for adult patients with cytogenetically intermediate and high-risk Acute Myeloid Leukemia (ALLG AMLM22/D4 CADENCE)

Free
Victoria Ling, Paula Marlton, John Reynolds, Mark Dawson, Robin Gasiorowski, Hannah Rose, Chun Yew Fong, Jake Shortt, Anoop Enjeti, Carolyn Grove, Joanna Nkyekyer, Nadia Munsef, Andrew Wei
Journal: Blood
Blood (2025) 146 (Supplement 1): 5210.
https://doi.org/10.1182/blood-2025-5210
Published: 2025
Journal Articles

Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies

Free
Tapan Kadia, Patricia Kropf, Michael Leahy, Chong Chyn Chua, Shaun Fleming, Caspian Oliai, John Kwan, Chun Yew Fong, Joshua Richmond, Paul Cannell, James Dugan, Maria Baer, Stephen Ting, Daniel Egan, Zi Chen, Qian Niu, Mingyu Li, Divya Mekala, Zhiyan Liang, Mohammad Ahmad, Yifan Zhai
Journal: Blood
Blood (2025) 146 (Supplement 1): 1641.
https://doi.org/10.1182/blood-2025-1641
Published: 2025
Journal Articles

Efficacy and safety of venetoclax plus azacitidine for patients with treatment-naive high-risk myelodysplastic syndromes

Open Access
Clinical Trials & Observations
Jacqueline S. Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Uma Borate, Meagan A. Jacoby, Daniel Nowak, Maria R. Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Journal: Blood
Blood (2025) 145 (11): 1126–1135.
https://doi.org/10.1182/blood.2024025464
Published: 2025
Includes: Supplemental data
Journal Articles

Efficacy and Safety of Uproleselan Combined with Chemotherapy Vs. Chemotherapy Alone in Relapsed/Refractory Acute Myeloid Leukemia: Findings from an International Phase 3 Trial

Free
Daniel J. DeAngelo, Andre C. Schuh, Brian A. Jonas, Pamela S. Becker, Anjali S. Advani, Geoffrey L. Uy, Janusz Krawczyk, Harry P. Erba, Gabriel N Mannis, Chun Yew Fong, Florian Kuchenbauer, Mary-Elizabeth M. Percival, Jane L. Liesveld, William Blum, Brenda W Cooper, Alice Mims, Francesco Lanza, Jeroen J.W.M. Janssen, Juan Miguel Bergua Burgues, Tibor Kovacsovics, Norbert Vey, Martina V. Hemmer, Gaetano Bonifacio, Edwin Rock, Pau Montesinos
Journal: Blood
Blood (2024) 144 (Supplement 1): 733.
https://doi.org/10.1182/blood-2024-209097
Published: 2024
Journal Articles

Health-Related Quality of Life in Adolescents and Young Adults Treated with Blinatumomab Consolidation for CD19+ Ph-Negative Acute Lymphoblastic Leukemia in the Australasian Lymphoma and Leukaemia Group (ALLG) ALL09 “Sublime” Study

Free
Omali Pitiyarachchi, Madeleine T King, Shane Gangatharan, Michael Osborn, Ashley P Ng, Shaun Fleming, Pasquale Fedele, Toby N Trahair, John Casey, Sally Mapp, Carol CY Cheung, Tasman Armytage, Philip McCloud, Peter Button, Leesa Rowley, Stephen Robert Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla-Pozza, Matthew Greenwood
Journal: Blood
Blood (2024) 144 (Supplement 1): 1445.
https://doi.org/10.1182/blood-2024-209043
Published: 2024
Journal Articles

Clinical Response to Azacitidine in Myelodysplastic Neoplasms Is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor Cells In Vivo

Free
Julie A.I. Thoms, Feng Yan, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Jesslyn Saw, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C Nunez, Purvi M. Kakadia, Golam Sarower Bhuyan, Xiaoheng Zou, Mary Nguyen, Elaheh S Ghodousi, Forrest C Koch, Fatemeh Vafaee, I. Richard Thompson, Mohammad M. Karimi, Russell Pickford, Mark J Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H Passam, Stephen Robert Larsen, Kevin J Spring, Kristen K Skarratt, Patricia Rebeiro, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop K Enjeti, Dirk Hoenemann, Charlotte Lemech, Christopher J Jolly, Stefan K. Bohlander, David J. Curtis, Jason Wong, Ashwin Unnikrishnan, Mark S. Hertzberg, Jake Olivier, Mark N Polizzotto, John E Pimanda
Journal: Blood
Blood (2024) 144 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2024-201216
Published: 2024
Journal Articles

Real-World Patterns of Care and Outcomes for Non-Favourable Risk Acute Myeloid Leukemia Treated with Intensive Chemotherapy across Australia and New Zealand- Data Linkage between the ALLG National Blood Cancer Registry (NBCR) and the Australia and New Zealand Transplant and Cellular Therapy (ANZTCT) Registry

Free
Nisha Thiagarajah, Mark R Dowling, Karin Dunne, Donna Aarons, Jenny Collins, Steven Tran, Shaun Fleming, Gaurav Sutrave, Devendra Hiwase, Chun Yew Fong, Blake Hsu, Duncan Purtill, Anne-Marie Watson, Glen A Kennedy, William S Stevenson, Stephen Robert Larsen, John Moore, Travis Perera, David S. Ritchie, Andrew Wei, Andrew W. Roberts, Nada Hamad, Ashish Bajel
Journal: Blood
Blood (2024) 144 (Supplement 1): 3799.
https://doi.org/10.1182/blood-2024-209389
Published: 2024
Journal Articles

CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity

Free
Kelly Lim, Monika Kutyna, Winnie Kan, Angel F. Lopez, Anna Brown, Agnes S. M. Yong, Steven W Lane, Chun Yew Fong, Timothy P Hughes, David T Yeung, David M Ross, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 3196.
https://doi.org/10.1182/blood-2024-202682
Published: 2024
Journal Articles

Durable Responses Observed in Chronic Myelomonocytic Leukemia Treated with Lenzilumab and Azacitidine

Free
Devendra Hiwase, David M Ross, David T Yeung, Agnes S. M. Yong, Steven W Lane, Anna Brown, Chun Yew Fong, Timothy P Hughes, John Reynolds, Daniel Thomas
Journal: Blood
Blood (2024) 144 (Supplement 1): 1006.
https://doi.org/10.1182/blood-2024-202867
Published: 2024
Journal Articles

Sorafenib plus intensive chemotherapy in newly diagnosed FLT3 -ITD AML: a randomized, placebo-controlled study by the ALLG

Free
Clinical Trials & Observations
Sun Loo, Andrew W. Roberts, Natasha S. Anstee, Glen A. Kennedy, Simon He, Anthony P. Schwarer, Anoop K. Enjeti, James D’Rozario, Paula Marlton, Ian A. Bilmon, John Taper, Gavin Cull, Campbell Tiley, Emma Verner, Uwe Hahn, Devendra K. Hiwase, Harry J. Iland, Nick Murphy, Sundra Ramanathan, John Reynolds, Doen Ming Ong, Ing Soo Tiong, Meaghan Wall, Michael Murray, Tristan Rawling, Joanna Leadbetter, Leesa Rowley, Maya Latimer, Sam Yuen, Stephen B. Ting, Chun Yew Fong, Kirk Morris, Ashish Bajel, John F. Seymour, Mark J. Levis, Andrew H. Wei
Journal: Blood
Blood (2023) 142 (23): 1960–1971.
https://doi.org/10.1182/blood.2023020301
Published: 2023
Includes: Supplemental data
Journal Articles

Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

Free
Monika Kutyna, Maha M Kamel, David M. Ross, Agnes S. M. Yong, Chun Yew Fong, Chloe Thompson-Peach, Steven W. Lane, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1852.
https://doi.org/10.1182/blood-2023-179706
Published: 2023
Journal Articles

Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

Free
Devendra Hiwase, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2023-179688
Published: 2023
Journal Articles

Phase 3b Study Design for a Comparison of Treatment Preference between Oral Decitabine/Cedazuridine and Azacitidine in Adult Patients with IPSS-R Intermediate Myelodysplastic Syndrome, IPSS Intermediate-2 or High-Risk Myelodysplastic Syndrome, Low-Blast Acute Myeloid Leukaemia, or Chronic Myelomonocytic Leukaemia

Free
Anoop K Enjeti, Chun Yew Fong, Francesco Castaldi, Greg van Wyk, Richard Walton, Taliesha Paine, Harold N. Keer
Journal: Blood
Blood (2023) 142 (Supplement 1): 7296.
https://doi.org/10.1182/blood-2023-179664
Published: 2023
Journal Articles

BMS-986158, a Potent BET Inhibitor, in Combination with Ruxolitinib or Fedratinib in Patients (pts) with Intermediate- or High-Risk Myelofibrosis (MF): Updated Results from a Phase 1/2 Study

Free
David Lavie, Vincent Ribrag, Michael Loschi, Costas K. Yannakou, Maan Alwan, Adi Schacham Abulafia, Jesús María Hernández-Rivas, Yulia Volchek, Chun Yew Fong, Massimiliano Bonifacio, Jean-Jacques Kiladjian, Jean-Christophe Ianotto, Valentín García Gutiérrez, Alessandra Tucci, Blanca Xicoy, Haifa Kathrin Al-Ali, Moshe Talpaz, Jonathan M. Gerber, Indu Raman, Ciprian Tomuleasa, Si Tuen Lee-Hoeflich, Sharmila Das, Bin Wu, Qian Zhao, Eunhee Kim, Oriana Esposito, Yu Liu, Zariana Nikolova, Christopher Tehlirian, Shodeinde Coker, Rosa Ayala
Journal: Blood
Blood (2023) 142 (Supplement 1): 623.
https://doi.org/10.1182/blood-2023-179160
Published: 2023
Journal Articles

Improved MRD Negativity Rates in Adverse Genomic Risk B-ALL Patients with Chemotherapy / Blinatumomab Induction: Experience from the Australasian Leukaemia Lymphoma Group (ALLG) ALL06/09 Studies

Free
Deborah L White, Jacqueline A Rehn, Caitlin E Schutz, Susan L Heatley, Laura N Eadie, Ashlee Thomson, Elyse C Page, Michael Osborn, Shane Gangatharan, Ashley P Ng, Shaun Fleming, Pasquale Fedele, Toby Trahair, John Casey, Sally Mapp, Carol CY Cheung, Tasman Armytage, Michelle Henderson, Rosemary Sutton, Stephen Robert Larsen, Peter Presgrave, John Kwan, Samuel Bennett, Chun Yew Fong, Luciano Dalla-Pozza, David T Yeung, Matthew Greenwood
Journal: Blood
Blood (2023) 142 (Supplement 1): 1609.
https://doi.org/10.1182/blood-2023-178473
Published: 2023
Journal Articles

Efficacy and Safety of Venetoclax in Combination with Azacitidine for the Treatment of Patients with Treatment-Naive, Higher-Risk Myelodysplastic Syndromes

Free
Jacqueline S. Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun Fleming, Chun Yew Fong, Rachel Cook, Meagan Jacoby, Daniel Nowak, Brenda Chyla, Ying Zhou, Grace Ku, Jalaja Potluri, Guillermo Garcia-Manero
Journal: Blood
Blood (2023) 142 (Supplement 1): 319.
https://doi.org/10.1182/blood-2023-189446
Published: 2023
Journal Articles

Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

Free
Maha M Kamel, Monika Kutyna, David M. Ross, Steven W. Lane, Chloe Thompson-Peach, Chun Yew Fong, Agnes S. M. Yong, David T Yeung, Timothy P Hughes, Devendra Hiwase, Daniel Thomas
Journal: Blood
Blood (2023) 142 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2023-188340
Published: 2023