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Journal Articles

A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia

Free
Samuel Yates, Elizabeth Terman, Lauren Miller, John Cursio, Claire Wild, Megan Huisingh-Scheetz, Michael Zhang, Nicholas Feinberg, Karteek Popuri, Mirza Faisal Beg, Varun Akella, Hamed Youshanlouei, Afsheen Noorani, Jamie Mathews, Caner Saygin, Anand Patel, Olatoyosi Odenike, Richard Larson, Mariam Nawas, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 5153.
https://doi.org/10.1182/blood-2025-5153
Published: 2025
Journal Articles

Molecular subtypes and BH3 mimetic synergy with anti-leukemia agents in T-cell acute lymphoblastic leukemia

Free
Satoshi Yoshimura, Yizhen Li, Xu Yang, Christian Meyer, Guoqing Du, Yu-Chih Hsiao, Zhenhua Li, Wenjian Yang, Courtney Andersen, Caner Saygin, Seth Karol, Kathrin Bernt, Jiyang Yu, Wendy Stock, David Teachey, Marina Konopleva, Jun J. Yang
Journal: Blood
Blood (2025) 146 (Supplement 1): 5081.
https://doi.org/10.1182/blood-2025-5081
Published: 2025
Journal Articles

Trial in progress – a phase 1b trial of ivosidenib combined with ruxolitinib in IDH1-mutated advanced myeloproliferative neoplasms

Free
Anand Patel, Theodore Karrison, Emily Dworkin, Rafael Madero-Marroquin, Austin Wesevich, Gregory Roloff, Caner Saygin, Mariam Nawas, Michael Drazer, Adam Duvall, Satyajit Kosuri, Michael Thirman, Wendy Stock, Richard Larson, Olatoyosi Odenike
Journal: Blood
Blood (2025) 146 (Supplement 1): 5608.
https://doi.org/10.1182/blood-2025-5608
Published: 2025
Journal Articles

Spiritual wellness and quality-of-life in adult patients with newly diagnosed acute leukemia receiving initial therapy: Patient-reported outcomes (PROs) from a prospective observational study

Free
Hannah Johnston, Abigail Sneider, Tuula Pera, Rafael Madero-Marroquin, Austin Wesevich, Gregory Roloff, Mariam Nawas, Anand Patel, Michael Drazer, Adam Duvall, Satyajit Kosuri, Michael Thirman, Olatoyosi Odenike, Richard Larson, Caner Saygin, Wendy Stock, Christopher Daugherty
Journal: Blood
Blood (2025) 146 (Supplement 1): 6382.
https://doi.org/10.1182/blood-2025-6382
Published: 2025
Journal Articles

Increased yield of recurrent structural variants (SVs) in Ph-like B-cell acute lymphoblastic leukemia (B-ALL) using a streamlined clinical whole-genome sequencing (WGS) assay

Free
Andrew Hughes, Feiyu Du, Michele O'Laughlin, Gregory Sprenger, Mohamed Mahgoub, Nidhi Davarapalli, Heidi Struthers, Haley Abel, Christopher Manring, Richard Harvey, Caner Saygin, Jun Yin, Jun J. Yang, Daniel Deangelo, Shira Dinner, Richard Stone, Marina Konopleva, Ann-Kathrin Eisfeld, Molly Schroeder, Eric Duncavage, Anjali Advani, Wendy Stock, Geoffrey Uy, David Spencer
Journal: Blood
Blood (2025) 146 (Supplement 1): 1590.
https://doi.org/10.1182/blood-2025-1590
Published: 2025
Journal Articles

Prospective analysis and clinical implications of therapy-related clonal hematopoiesis in adolescent and young adult survivors of acute lymphoblastic leukemia

Free
Habib El-Khoury, Ella Postich, Diren Arda Karaoglu, Aishwarya Atmakuri, Hamed Rahmani Youshalouei, Adam Duvall, Wendy Stock, Tara Henderson, Caner Saygin
Journal: Blood
Blood (2025) 146 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2025-3319
Published: 2025
Journal Articles

Inotuzumab ozogamicin then blinatumomab for older adults with newly diagnosed, ph-negative, CD22-positive, B-cell acute lymphoblastic leukemia: Extended follow-up of alliance for clinical trials in oncology A041703 cohort 1 reveals durable remission and survival

Free
Matthew Wieduwilt, Jun Yin, Oudom Kour, Rebecca Teske, Wendy Stock, Carolin Escherich, Jun J. Yang, Zhenhua Li, Ken Byrd, Kimberley Doucette, James Mangan, Scott Hall, Alice Mims, Katarzyna Jamieson, Shira Dinner, Ali Bseiso, Georgia Giordano, Caner Saygin, Geoffrey Uy, Mark Litzow, Richard Stone
Journal: Blood
Blood (2025) 146 (Supplement 1): 444.
https://doi.org/10.1182/blood-2025-444
Published: 2025
Journal Articles

Primary efficacy analysis of phase II study investigating tyrosine kinase inhibitor (TKI) and inotuzumab ozogamicin-based therapy for newly diagnosed Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL)

Free
Anand Patel, Adam Duvall, Caner Saygin, Howard Weiner, Emily Dworkin, Afsheen Noorani, Jamie Mathews, Angela Lager, Sandeep Gurbuxani, Peng Wang, Rafael Madero-Marroquin, Austin Wesevich, Michael Drazer, Mariam Nawas, Gregory Roloff, Satyajit Kosuri, Michael Thirman, Richard Larson, Olatoyosi Odenike, Theodore Karrison, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 441.
https://doi.org/10.1182/blood-2025-441
Published: 2025
Journal Articles

Granulocyte maturation and splicing defects in DDX41-mutated leukemia

Free
Ira Kraft, Jeremy Scutenaire, Ayush Raman, Trinh Pham, Ronald Holewinski, Kathy McGraw, Srinivas Tantravahi, Caner Saygin, Anthony Pomicter, Benjamin Donovan, Liqiang Xi, Yi Liu, Murali Palangat, Katherine McKinnon, Alain Mina, Rebecca Alexander, Thorkell Andresson, Mark Raffeld, Markus Hafner, Daniel Larson
Journal: Blood
Blood (2025) 146 (Supplement 1): 1439.
https://doi.org/10.1182/blood-2025-1439
Published: 2025
Journal Articles

Trial in progress: A Phase I/II study to investigate the combination of LP-118, ponatinib, vincristine and dexamethasone (LPVd regimen) in relapsed/refractory T-ALL/lbl

Free
Caner Saygin, Anand Patel, Hannah Levavi, Kristen O'Dwyer, Meixiao Long, Fernando Vargas Madueno, Chenyu Lin, Theodore Karrison, Howard Weiner, Adam Duvall, Satyajit Kosuri, Rafael Madero-Marroquin, Gregory Roloff, Michael Drazer, Michael Thirman, Richard Larson, Olatoyosi Odenike, L. Evan Reddick, Yu Chen, Stephen Anthony, Wendy Stock
Journal: Blood
Blood (2025) 146 (Supplement 1): 5136.
https://doi.org/10.1182/blood-2025-5136
Published: 2025
Journal Articles

Type 2 calreticulin mutations activate ATF6 to promote BCL-xL–mediated survival in myeloproliferative neoplasms

Available to Purchase
Nicole S. Arellano, William L. Heaton, Mirielle C. Nauman, Abigail E. Runnels, Jacky Gomez-Villa, Daniele Vanni, Melissa Gaviria, Maihi Fujita, Nathan M. Krah, Michele Ciboddo, Saveg Yadav, Callie T. Brown, Parker D. Bowden, Amy K. Chen, Christopher Henning, Silvia Catricalà, Ilaria Carola Casetti, Oscar Borsani, Elisa Rumi, Daniela Pietra, Isabelle Plo, Caroline Marty, Marco Marchetti, Ami B. Patel, Caner Saygin, Shannon E. Elf
Journal: Blood
Blood (2025) 146 (8): 971–983.
https://doi.org/10.1182/blood.2024026940
Published: 2025
Includes: Supplemental data
Journal Articles

Risk prediction for clonal cytopenia: multicenter real-world evidence

Free
Clinical Trials & Observations
Zhuoer Xie, Rami Komrokji, Najla Al Ali, Alexandra Regelson, Susan Geyer, Anand Patel, Caner Saygin, Amer M. Zeidan, Jan Philipp Bewersdorf, Lourdes Mendez, Ashwin Kishtagari, Joshua F. Zeidner, Catherine C. Coombs, Yazan F. Madanat, Stephen Chung, Talha Badar, James Foran, Pinkal Desai, Charlton Tsai, Elizabeth A. Griffiths, Monzr M. Al Malki, Idoroenyi Amanam, Catherine Lai, H. Joachim Deeg, Lionel Ades, Cecilia Arana Yi, Afaf E. G. Osman, Shira Dinner, Yasmin Abaza, Justin Taylor, Namrata Chandhok, Deborah Soong, Andrew M. Brunner, Hetty E. Carraway, Abhay Singh, Chiara Elena, Jacqueline Ferrari, Anna Gallì, Sara Pozzi, Eric Padron, Mrinal M. Patnaik, Luca Malcovati, Michael R. Savona, Aref Al-Kali
Journal: Blood
Blood (2024) 144 (19): 2033–2044.
https://doi.org/10.1182/blood.2024024756
Published: 2024
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing-Based T-Cell Receptor (TR) Measurable Residual Disease Monitoring Does Not Predict Relapse in T-Lineage Acute Lymphoblastic Leukemia

Free
Rafael Madero-Marroquin, Adnan Askari, Yenny Vanegas Moreno, Clare E Anderson, Talha Badar, Guru Subramanian Guru Murthy, Chenyu Lin, Alexander Coltoff, Adam S. Duvall, Richard A. Larson, Olatoyosi Odenike, Wendy Stock, Anand Ashwin Patel, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 5937.
https://doi.org/10.1182/blood-2024-203665
Published: 2024
Journal Articles

Outcomes of BCR::ABL1 -like B-Lineage Acute Lymphoblastic Leukemia in the Era of Novel Therapies

Free
Hamed Rahmani Youshanlouei, Syed Shah, Francisca Anazco, Anand Ashwin Patel, Adam S. Duvall, Gregory W Roloff, Michael W Drazer, Satyajit Kosuri, Mariam T. Nawas, Angela Lager, Carrie Fitzpatrick, Peng Wang, Melissa Tjota, Sandeep Gurbuxani, Girish Venkataraman, Jason Xiaojun Cheng, Jeremy Segal, Olatoyosi Odenike, Richard A. Larson, Wendy Stock, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 5918.
https://doi.org/10.1182/blood-2024-208069
Published: 2024
Journal Articles

Evolution of Clonal Hematopoiesis after Discontinuation of Therapy for Multiple

Free
Jennifer H Cooperrider, Diren Arda Arda Karaoglu, Tadeusz Kubicki, Ken Jiang, Ella Postich, Kathryn Kimi Shimamoto, Olivia Arnold, Aubrianna Ramsland, Anna Pula, Jommel Macaraeg, Andrzej J Jakubowiak, Benjamin A Derman, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 253.
https://doi.org/10.1182/blood-2024-208256
Published: 2024
Journal Articles

Addition of Inotuzumab to a Pediatric Inspired Chemotherapy Regimen in Young Adult Patients with B-Cell Acute Lymphoblastic Leukemia: Findings from the Alliance A041501 Phase 3 Randomized Trial

Free
Daniel J. DeAngelo, Jun Yin, Anjali S. Advani, Selina Luger, Jill Fulcher, Michaela Liedtke, Geoffrey L. Uy, Shira N. Dinner, Lindsay Wilde, Marlise R. Luskin, Caner Saygin, Ella Postich, Noreen Fulton, Richard C. Harvey, Gaby E Perez Burbano, Rebecca Teske, Harry P. Erba, Mark R. Litzow, Richard M. Stone, Wendy Stock
Journal: Blood
Blood (2024) 144 (Supplement 1): 308.
https://doi.org/10.1182/blood-2024-209438
Published: 2024
Journal Articles

Pathogenic Germline Variants in the DNA Damage Repair Pathway Are Enriched in Patients with Hematologic Malignancies with Prior Exposure to Cytotoxic Therapies Compared to Patients with Multiple Cancers without Prior Exposure

Free
Devendra Hiwase, Zoe Price, Chung How Kok, Monika Kutyna, Deepak Singhal, Naranie Shanmuganathan, Lesley Rawlings, David M Ross, David T Yeung, Anna Brown, Christopher N. Hahn, Lucy Godley, Caner Saygin, Hamish S Scott
Journal: Blood
Blood (2024) 144 (Supplement 1): 4596.
https://doi.org/10.1182/blood-2024-211795
Published: 2024
Journal Articles

Interim Results of a Phase II Study Investigating Dasatinib and Inotuzumab Ozogamicin-Based Induction for Newly-Diagnosed Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Free
Anand Ashwin Patel, Adam S. Duvall, Caner Saygin, Howard Weiner, Emily Dworkin, Afsheen Noorani, Jamie Matthews, Rafael Madero Marroquin, Michael W Drazer, Mariam T. Nawas, Gregory W Roloff, Satyajit Kosuri, Michael J. Thirman, Richard A. Larson, Olatoyosi Odenike, Theodore Karrison, Wendy Stock
Journal: Blood
Blood (2024) 144 (Supplement 1): 1432.
https://doi.org/10.1182/blood-2024-193442
Published: 2024
Journal Articles

Clinical Implications of Treatment-Related Clonal Hematopoiesis in Adolescent and Young Adult Survivors of Acute Lymphoblastic Leukemia

Free
Habib El-Khoury, Ella Postich, Diren Arda Karaoglu, Aishwarya Atmakuri, Hamed Rahmani Youshalouei, Syed Shah, Wendy Stock, Tara O. Henderson, Adam Duvall, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1429.
https://doi.org/10.1182/blood-2024-211655
Published: 2024
Journal Articles

Targeting Menin in T-Lineage Acute Lymphoblastic Leukemia

Free
Kathryn Kimi Shimamoto, Arda Arda Karaoglu, Zachary Chan, Giorgia Giordano, Bartholomew Eisfelder, Jason Xiaojun Cheng, Hamed Youshanlouei, Syed Shah, Anand Ashwin Patel, Adam S. Duvall, Francis Burrows, Linda Kessler, Michael W Drazer, Olatoyosi Odenike, Michael J. Thirman, Wendy Stock, Caner Saygin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1452.
https://doi.org/10.1182/blood-2024-201741
Published: 2024